[HTML][HTML] The SH-SY5Y cell line in Parkinson's disease research: a systematic review

H Xicoy, B Wieringa, GJM Martens - Molecular neurodegeneration, 2017 - Springer
Parkinson's disease (PD) is a devastating and highly prevalent neurodegenerative disease
for which only symptomatic treatment is available. In order to develop a truly effective …

Advancement in the modelling and therapeutics of Parkinson's disease

SN Rai, P Singh - Journal of chemical neuroanatomy, 2020 - Elsevier
Since the discovery of L-dopa in the middle of the 20th century (1960s), there is not any
neuroprotective therapy available although significant development has been made in the …

Control of cell state transitions

OS Rukhlenko, M Halasz, N Rauch, V Zhernovkov… - Nature, 2022 - nature.com
Understanding cell state transitions and purposefully controlling them is a longstanding
challenge in biology. Here we present cell state transition assessment and regulation …

[HTML][HTML] Use of human neuroblastoma SH-SY5Y cells to evaluate glyphosate-induced effects on oxidative stress, neuronal development and cell death signaling …

MA Martínez, JL Rodríguez, B Lopez-Torres… - Environment …, 2020 - Elsevier
Glyphosate-containing herbicides are the most used agrochemicals in the world. Their
indiscriminate application raises some concerns regarding the possible health and …

Characterization of differentiated SH-SY5Y as neuronal screening model reveals increased oxidative vulnerability

JI Forster, S Köglsberger, C Trefois… - Journal of …, 2016 - journals.sagepub.com
The immortalized and proliferative cell line SH-SY5Y is one of the most commonly used cell
lines in neuroscience and neuroblastoma research. However, undifferentiated SH-SY5Y …

[HTML][HTML] The cellular model for Alzheimer's disease research: PC12 cells

D Xie, T Deng, Z Zhai, T Sun, Y Xu - Frontiers in Molecular …, 2023 - frontiersin.org
Alzheimer's disease (AD) is a common age-related neurodegenerative disease
characterized by progressive cognitive decline and irreversible memory impairment …

[HTML][HTML] RBM45 is an m6A-binding protein that affects neuronal differentiation and the splicing of a subset of mRNAs

SH Choi, MN Flamand, B Liu, H Zhu, M Hu, M Wang… - Cell reports, 2022 - cell.com
Summary N 6-methyladenosine (m 6 A) is deposited co-transcriptionally on thousands of
cellular mRNAs and plays important roles in mRNA processing and cellular function. m 6 A …

[HTML][HTML] Neuroprotective and anti-inflammatory effects of linoleic acid in models of parkinson's disease: the implication of lipid droplets and lipophagy

J Alarcon-Gil, A Sierra-Magro, JA Morales-Garcia… - Cells, 2022 - mdpi.com
Parkinson's disease (PD) is the second most prevalent neurodegenerative disease after
Alzheimer's disease. The principal pathological feature of PD is the progressive loss of …

[HTML][HTML] Lactoferrin ameliorates dopaminergic neurodegeneration and motor deficits in MPTP-treated mice

SF Xu, YH Zhang, S Wang, ZQ Pang, YG Fan, JY Li… - Redox biology, 2019 - Elsevier
Brain iron accumulation is common in patients with Parkinson's disease (PD). Iron chelators
have been investigated for their ability to prevent neurodegenerative diseases with features …

[HTML][HTML] Neuroprotective effect of luteolin-7-O-glucoside against 6-OHDA-induced damage in undifferentiated and RA-differentiated SH-SY5Y cells

SCH Rehfeldt, J Silva, C Alves, S Pinteus… - International Journal of …, 2022 - mdpi.com
Luteolin is one of the most common flavonoids present in edible plants and its potential
benefits to the central nervous system include decrease of microglia activation, neuronal …