Gastric cancer (GC) ranks fifth in global cancer diagnosis and fourth in cancer-related death.
Despite tremendous progress in diagnosis and therapeutic strategies and significant …

Renal fibrosis, particularly tubulointerstitial fibrosis, is the common final outcome of almost
all progressive chronic kidney diseases. Renal fibrosis is also a reliable predictor of …

Modulations of cytoskeletal organization and focal adhesion turnover correlate to
tumorigenesis and epithelial-mesenchymal transition (EMT), the latter process accompanied …

Kidney fibrosis is the final common pathway of progressive kidney diseases, the underlying
mechanisms of which are not fully understood. The purpose of the current study is to …

Interstitial fibrosis is an important contributor to graft loss in chronic renal allograft injury.
Inflammatory macrophages are associated with fibrosis in renal allografts, but how these …

Sphingomyelin synthase (SMS), which comprises of two isozymes, SMS1 and SMS2, is the
only enzyme that generates sphingomyelin (SM) by transferring phosphocholine of …

Homeostasis is a prerequisite for health. When homeostasis becomes disrupted, dysfunction
occurs. This is especially the case for the gut microbiota, which under normal conditions …

Renal interstitial fibrosis: mechanisms and evaluation : Current Opinion in Nephrology and
Hypertension Renal interstitial fibrosis: mechanisms and evaluation : Current Opinion in …

Background Uremic toxins are considered to have a determinant pathological role in the
progression of chronic kidney disease. The aim of this study was to define the putative …

Focal adhesion (FA) assembly, mediated by integrin activation, responds to matrix stiffness;
however, the underlying mechanisms are unclear. Here, we showed that β1 integrin and …