Circadian clocks are endogenous oscillators that control 24-h physiological and behavioral
processes. The central circadian clock exerts control over myriad aspects of mammalian …

Recent discoveries demonstrate a critical role for circadian rhythms and sleep in immune
system homeostasis. Both innate and adaptive immune responses—ranging from leukocyte …

African trypanosomes are bloodstream protozoan parasites that infect mammals including
humans, where they cause sleeping sickness. Long-lasting infection is required to favor …

The circadian system is composed of coupled endogenous oscillators that allow living
beings, including humans, to anticipate and adapt to daily changes in their environment. In …

Human African trypanosomiasis, or sleeping sickness, is caused by the protozoan parasite
Trypanosoma brucei and induces profound reactivity of glial cells and neuroinflammation …

Malarial rhythmic fevers are the consequence of the synchronous bursting of red blood cells
(RBCs) on completion of the malaria parasite asexual cell cycle. Here, we hypothesized that …

The circadian clock controls daily rhythms of physiological processes. The presence of the
clock mechanism throughout the body is hampering its local regulation by small molecules …

Parasitic diseases, such as sleeping sickness, Chagas disease and malaria, remain a major
cause of morbidity and mortality worldwide, but particularly in tropical, developing countries …

Biological rhythms coordinate organisms' activities with daily rhythms in the environment.
For parasites, this includes rhythms in both the external abiotic environment and the within …

The circadian clock provides organisms with the ability to track time of day, allowing them to
predict and respond to cyclical changes in the external environment. In mammals this clock …