The maintenance and preservation of distinct phases during the cell cycle is a highly
complex and coordinated process. It is regulated by phosphorylation—through the activity of …

Introduction: Endometrial cancer is the most common gynaecological cancer and its
incidence is rising due to increasing obesity rates. We are also seeing an increasing trend of …

AFX-like Forkhead transcription factors, which are controlled by phosphatidylinositol 3-
kinase (PI3K)/protein kinase B (PKB) signaling, are involved in regulating cell cycle …

Inactivation of the retinoblastoma (RB1) tumor suppressor is one of the most frequent and
early recognized molecular hallmarks of cancer. RB1, although mainly studied for its role in …

This review summarizes reports of recurrent DNA sequence copy number losses in human
neoplasms detected by comparative genomic hybridization. Recurrent losses that affect …

Over the last decade, a growing number of tumor suppressor genes have been discovered
to play a role in tumorigenesis. Mutations of p53 have been found in hematological …

p107 and p130 were originally identified as targets of the transforming domains of viral
oncoproteins encoded by small DNA tumor viruses. Together with pRB, the protein product …

p130 is a tumor suppressor of the pocket protein family whose expression is
posttranscriptionally regulated and largely G0 restricted. The mechanism of down-regulation …

Molecular markers have the potential to serve not only as prognostic factors but may be
targets for new therapeutic strategies and predictors of response in a range of cancers …

Based on high quality surgery and scientific data, scientists and surgeons are committed to
protecting patients as well as healthcare staff and hereby provide this Guidance to address …