Histone deacetylases (HADC) are the enzymes that remove acetyl group from lysine residue
of histones and non-histone proteins and regulate the process of transcription by binding to …

In the fatal disease—amyotrophic lateral sclerosis (ALS)—upper (corticospinal) motor
neurons (MNs) and lower somatic MNs, which innervate voluntary muscles, degenerate …

Long-lasting memories require specific gene expression programmes that are, in part,
orchestrated by epigenetic mechanisms. Of the epigenetic modifications identified in …

The mood stabilizers lithium and valproic acid (VPA) are traditionally used to treat bipolar
disorder (BD), a severe mental illness arising from complex interactions between genes and …

Histone deacetylases (HDACs) play a key role in homeostasis of protein acetylation in
histones and other proteins and in regulating fundamental cellular activities such as …

Histone deacetylases (HDACs)—enzymes that affect the acetylation status of histones and
other important cellular proteins—have been recognized as potentially useful therapeutic …

Over the past decade, it has become increasingly obvious that epigenetic mechanisms are
an integral part of a multitude of brain functions that range from the development of the …

Gain-of-function mutations in the Cu, Zn-superoxide dismutase (SOD1) gene are implicated
in progressive motor neuron death and paralysis in one form of inherited amyotrophic lateral …

Over the past 20 years, there has been a drastically increased understanding of the genetic
basis of Amyotrophic Lateral Sclerosis. Despite the identification of more than 40 different …

Valproic acid (VPA, 2-propylpentanoic acid) has been widely used as an antiepileptic drug
and for the therapy of bipolar disorders for several years. Its mechanism of action was …