Neutrophils as emerging therapeutic targets
Neutrophils are the most abundant circulating leukocytes, being the first line of defence
against bacterial and fungal infections. However, neutrophils also contribute to tissue …
against bacterial and fungal infections. However, neutrophils also contribute to tissue …
Strategies toward rheumatoid arthritis therapy; the old and the new
Currently, medications used to treat rheumatoid arthritis (RA) are glucocorticoids (GCs) and
nonsteroidal anti‐inflammatory drugs (NSAIDs), predominantly used for controlling the pain …
nonsteroidal anti‐inflammatory drugs (NSAIDs), predominantly used for controlling the pain …
The pathogenesis of rheumatoid arthritis
IB McInnes, G Schett - New England Journal of Medicine, 2011 - Mass Medical Soc
The Pathogenesis of Rheumatoid Arthritis | New England Journal of Medicine Skip to main
content The New England Journal of Medicine homepage Advanced Search SEARCH …
content The New England Journal of Medicine homepage Advanced Search SEARCH …
Therapeutic blockade of granulocyte macrophage colony-stimulating factor in COVID-19-associated hyperinflammation: challenges and opportunities
The COVID-19 pandemic is a global public health crisis, with considerable mortality and
morbidity exerting pressure on health-care resources, including critical care. An excessive …
morbidity exerting pressure on health-care resources, including critical care. An excessive …
Targeting GM-CSF in inflammatory diseases
IP Wicks, AW Roberts - Nature Reviews Rheumatology, 2016 - nature.com
Granulocyte-macrophage colony stimulating factor (GM-CSF) is a growth factor first
identified as an inducer of differentiation and proliferation of granulocytes and macrophages …
identified as an inducer of differentiation and proliferation of granulocytes and macrophages …
HBEGF+ macrophages in rheumatoid arthritis induce fibroblast invasiveness
Macrophages tailor their function according to the signals found in tissue
microenvironments, assuming a wide spectrum of phenotypes. A detailed understanding of …
microenvironments, assuming a wide spectrum of phenotypes. A detailed understanding of …
Emerging aspects of cytokine storm in COVID-19: The role of proinflammatory cytokines and therapeutic prospects
COVID-19 has claimed millions of lives during the last 3 years since initial cases were
reported in Wuhan, China, in 2019. Patients with COVID-19 suffer from severe pneumonia …
reported in Wuhan, China, in 2019. Patients with COVID-19 suffer from severe pneumonia …
Fate-mapping of GM-CSF expression identifies a discrete subset of inflammation-driving T helper cells regulated by cytokines IL-23 and IL-1β
J Komuczki, S Tuzlak, E Friebel, T Hartwig, S Spath… - Immunity, 2019 - cell.com
Pathogenic lymphocytes initiate the development of chronic inflammatory diseases. The
cytokine granulocyte-macrophage colony-stimulating factor (GM-CSF)(encoded by Csf2) is a …
cytokine granulocyte-macrophage colony-stimulating factor (GM-CSF)(encoded by Csf2) is a …
Dual role of GM-CSF as a pro-inflammatory and a regulatory cytokine: implications for immune therapy
P Bhattacharya, I Budnick, M Singh… - Journal of Interferon & …, 2015 - liebertpub.com
Granulocyte macrophage colony stimulating factor (GM-CSF) is generally recognized as an
inflammatory cytokine. Its inflammatory activity is primarily due its role as a growth and …
inflammatory cytokine. Its inflammatory activity is primarily due its role as a growth and …
Persistent arthralgia induced by Chikungunya virus infection is associated with interleukin-6 and granulocyte macrophage colony-stimulating factor
Background. Chikungunya virus (CHIKV) infection induces arthralgia. The involvement of
inflammatory cytokines and chemokines has been suggested, but very little is known about …
inflammatory cytokines and chemokines has been suggested, but very little is known about …