Determinants, maintenance, and function of organellar pH

SA Freeman, S Grinstein… - Physiological reviews, 2023 - journals.physiology.org
The protonation state of soluble and membrane-associated macromolecules dictates their
charge, conformation, and functional activity. In addition, protons (H+ or their equivalents) …

Mitochondrial cristae morphology reflecting metabolism, superoxide formation, redox homeostasis, and pathology

P Ježek, M Jabůrek, B Holendová… - Antioxidants & Redox …, 2023 - liebertpub.com
Significance: Mitochondrial (mt) reticulum network in the cell possesses amazing
ultramorphology of parallel lamellar cristae, formed by the invaginated inner mitochondrial …

Cristae undergo continuous cycles of membrane remodelling in a MICOS‐dependent manner

AK Kondadi, R Anand, S Hänsch, J Urbach, T Zobel… - EMBO …, 2020 - embopress.org
The mitochondrial inner membrane can reshape under different physiological conditions.
How, at which frequency this occurs in living cells, and the molecular players involved are …

Mitochondrial morphofunction in mammalian cells

EP Bulthuis, MJW Adjobo-Hermans… - Antioxidants & redox …, 2019 - liebertpub.com
Significance: In addition to their classical role in cellular ATP production, mitochondria are of
key relevance in various (patho) physiological mechanisms including second messenger …

A molecular rotor FLIM probe reveals dynamic coupling between mitochondrial inner membrane fluidity and cellular respiration

G Singh, G George, SO Raja… - Proceedings of the …, 2023 - National Acad Sciences
The inner mitochondrial membrane (IMM), housing components of the electron transport
chain (ETC), is the site for respiration. The ETC relies on mobile carriers; therefore, it has …

Reversible Live‐Cell Labeling with Retro‐engineered HaloTags Enables Long‐Term High‐and Super‐Resolution Imaging

M Holtmannspötter, E Wienbeuker… - Angewandte Chemie …, 2023 - Wiley Online Library
Self‐labeling enzymes (SLE) such as the HaloTag have emerged as powerful tools in high
and super‐resolution fluorescence microscopy. Newly developed fluorogenic SLE …

Collagen dynamics during the process of osteocyte embedding and mineralization

LA Shiflett, LAM Tiede-Lewis, Y Xie, Y Lu… - Frontiers in cell and …, 2019 - frontiersin.org
Bone formation, remodeling and repair are dynamic processes, involving cell migration,
ECM assembly, osteocyte embedding, and bone resorption. Using live-cell imaging, we …

[HTML][HTML] Inhibition of the mitochondrial ATPase function by IF1 changes the spatiotemporal organization of ATP synthase

V Weissert, B Rieger, S Morris, T Arroum… - … et Biophysica Acta (BBA …, 2021 - Elsevier
Mitochondrial F 1 FO ATP synthase is the key enzyme for mitochondrial bioenergetics.
Dimeric F 1 F O-ATP synthase, is preferentially located at the edges of the cristae and its …

[HTML][HTML] Pigment-protein complexes are organized into stable microdomains in cyanobacterial thylakoids

A Strašková, G Steinbach, G Konert, E Kotabová… - … et Biophysica Acta (BBA …, 2019 - Elsevier
Thylakoids are the place of the light-photosynthetic reactions. To gain maximal efficiency,
these reactions are conditional to proper pigment-pigment and protein-protein interactions …

Single molecule analyses reveal dynamics of Salmonella translocated effector proteins in host cell endomembranes

V Göser, N Sander, M Schulte, F Scharte… - Nature …, 2023 - nature.com
The facultative intracellular pathogen Salmonella enterica remodels the host endosomal
system for survival and proliferation inside host cells. Salmonella resides within the …