The cell wall (CW) of bacteria is an intricate arrangement of macromolecules, at least
constituted of peptidoglycan (PG) but also of (lipo) teichoic acids, various polysaccharides …

Antimicrobial resistance (AMR) is a global crisis for human public health which threatens the
effective prevention and control of ever-increasing infectious diseases. The advent of …

Deep-learning language models have shown promise in various biotechnological
applications, including protein design and engineering. Here we describe ProGen, a …

Over the past few decades, we have witnessed a surge around the world in the emergence
of antibiotic-resistant bacteria. This global health threat arose mainly due to the overuse and …

Bacterial drug resistance is rapidly developing as one of the greatest threats to human
health. Bacteria will adopt corresponding strategies to crack the inhibitory effect of antibiotics …

Bacteriophages (phages) are selective viral predators of bacteria. Abundant and ubiquitous
in nature, phages can be used to treat bacterial infections (phage therapy), including …

Bypassing nature's evolutionary trajectory, de novo protein generation—defined as creating
artificial protein sequences from scratch—could enable breakthrough solutions for …

Therapeutic bacteriophages, commonly called as phages, are a promising potential
alternative to antibiotics in the management of bacterial infections of a wide range of …

Bacterial pathogens are leading causes of infections with high mortality worldwide having a
great impact on healthcare systems and the food industry. Gold standard methods for …

The spread of bacterial strains resistant to commonly used antibiotics urges the
development of novel antibacterial compounds. Ideally, these novel antimicrobials should …