Extracellular matrix is rich in biomolecules including structural proteins,
glycosaminoglycans, and small molecules that are important for the maintenance and repair …

In view of their low immunogenicity, biomimetic internal environment, tissue-and organ-like
physicochemical properties, and functionalization potential, decellularized extracellular …

Hydrogel systems have been widely used to engineer biomimetic niches that capture
microenvironments cues to steer cell fate; however, challenges remain in inducing …

The development of interdisciplinary biomedical engineering brings significant
breakthroughs to the field of cartilage regeneration. However, cartilage defects are …

Tissue development, wound healing, pathogenesis, regeneration, and homeostasis rely
upon coordinated and dynamic spatial and temporal remodeling of extracellular matrix …

The complete healing of skin wounds has been a challenge in clinical treatment. Self-
healing hydrogels are special hydrogels formed by distinctive physicochemically reversible …

Although hydrogels exhibit excellent low frictional behavior, their friction coefficients cannot
meet the requirements for biology, especially at low sliding velocities. Inspired by the natural …

BACKGROUND: Intra-articular injection is a classic strategy for the treatment of early
osteoarthritis (OA). However, the local delivery of traditional therapeutic agents has limited …

Macrophages play a crucial role in the complete processes of tissue repair and
regeneration, and the activation of M2 polarization is an effective approach to provide a pro …

Cartilage injuries are common problems that increase with the population aging. Cartilage is
an avascular tissue with a relatively low level of cellular mitotic activity, which makes it …