Vascular niche in lung alveolar development, homeostasis, and regeneration

A Mammoto, T Mammoto - Frontiers in bioengineering and …, 2019 - frontiersin.org
Endothelial cells (ECs) constitute small capillary blood vessels and contribute to delivery of
nutrients, oxygen and cellular components to the local tissues, as well as to removal of …

Recruited monocytes and type 2 immunity promote lung regeneration following pneumonectomy

AJ Lechner, IH Driver, J Lee, CM Conroy, A Nagle… - Cell stem cell, 2017 - cell.com
To investigate the role of immune cells in lung regeneration, we used a unilateral
pneumonectomy model that promotes the formation of new alveoli in the remaining lobes …

Lung development and emerging roles for type 2 immunity

S Loering, GJM Cameron, MR Starkey… - The Journal of …, 2019 - Wiley Online Library
Lung development is a complex process mediated through the interaction of multiple cell
types, factors and mediators. In mice, it starts as early as embryonic day 9 and continues into …

SDF‐1/CXCR4 signalling is involved in blood vessel growth and remodelling by intussusception

I Dimova, S Karthik, A Makanya… - Journal of cellular …, 2019 - Wiley Online Library
The precise mechanisms of SDF‐1 (CXCL12) in angiogenesis are not fully elucidated.
Recently, we showed that Notch inhibition induces extensive intussusceptive angiogenesis …

Endothelial MT 1‐MMP targeting limits intussusceptive angiogenesis and colitis via TSP1/nitric oxide axis

S Esteban, C Clemente, A Koziol… - EMBO molecular …, 2020 - embopress.org
Pathological angiogenesis contributes to cancer progression and chronic inflammatory
diseases. In inflammatory bowel disease, the microvasculature expands by intussusceptive …

Sprouting and intussusceptive angiogenesis in postpneumonectomy lung growth: mechanisms of alveolar neovascularization

M Ackermann, JP Houdek, BC Gibney, A Ysasi… - Angiogenesis, 2014 - Springer
In most rodents and some other mammals, the removal of one lung results in compensatory
growth associated with dramatic angiogenesis and complete restoration of lung capacity …

Inhibition of Notch signaling induces extensive intussusceptive neo-angiogenesis by recruitment of mononuclear cells

I Dimova, R Hlushchuk, A Makanya, B Styp-Rekowska… - Angiogenesis, 2013 - Springer
Notch is an intercellular signaling pathway related mainly to sprouting neo-angiogenesis.
The objective of our study was to evaluate the angiogenic mechanisms involved in the …

Bridging lung development with chronic obstructive pulmonary disease. Relevance of developmental pathways in chronic obstructive pulmonary disease …

O Boucherat, MC Morissette, S Provencher… - American journal of …, 2016 - atsjournals.org
Chronic obstructive pulmonary disease (COPD) is characterized by chronic airflow limitation.
This generic term encompasses emphysema and chronic bronchitis, two common …

Alveologenesis: what governs secondary septa formation

AL Rippa, EV Alpeeva, AV Vasiliev… - International Journal of …, 2021 - mdpi.com
The simplification of alveoli leads to various lung pathologies such as bronchopulmonary
dysplasia and emphysema. Deep insight into the process of emergence of the secondary …

Inhibiting endothelial Rhoj blocks profibrotic vascular intussusception and angiocrine factors to sustain lung regeneration

J Ma, L Zhang, X Zhang, L Zhang, H Zhang… - Science Translational …, 2024 - science.org
Lung regeneration after fibrosis requires formation of functional new vasculature, which is
essential for gas exchange and cellular cross-talk with other lung cells. It remains unknown …