Vascular niche in lung alveolar development, homeostasis, and regeneration
A Mammoto, T Mammoto - Frontiers in bioengineering and …, 2019 - frontiersin.org
Endothelial cells (ECs) constitute small capillary blood vessels and contribute to delivery of
nutrients, oxygen and cellular components to the local tissues, as well as to removal of …
nutrients, oxygen and cellular components to the local tissues, as well as to removal of …
Recruited monocytes and type 2 immunity promote lung regeneration following pneumonectomy
To investigate the role of immune cells in lung regeneration, we used a unilateral
pneumonectomy model that promotes the formation of new alveoli in the remaining lobes …
pneumonectomy model that promotes the formation of new alveoli in the remaining lobes …
Lung development and emerging roles for type 2 immunity
Lung development is a complex process mediated through the interaction of multiple cell
types, factors and mediators. In mice, it starts as early as embryonic day 9 and continues into …
types, factors and mediators. In mice, it starts as early as embryonic day 9 and continues into …
SDF‐1/CXCR4 signalling is involved in blood vessel growth and remodelling by intussusception
The precise mechanisms of SDF‐1 (CXCL12) in angiogenesis are not fully elucidated.
Recently, we showed that Notch inhibition induces extensive intussusceptive angiogenesis …
Recently, we showed that Notch inhibition induces extensive intussusceptive angiogenesis …
Endothelial MT 1‐MMP targeting limits intussusceptive angiogenesis and colitis via TSP1/nitric oxide axis
S Esteban, C Clemente, A Koziol… - EMBO molecular …, 2020 - embopress.org
Pathological angiogenesis contributes to cancer progression and chronic inflammatory
diseases. In inflammatory bowel disease, the microvasculature expands by intussusceptive …
diseases. In inflammatory bowel disease, the microvasculature expands by intussusceptive …
Sprouting and intussusceptive angiogenesis in postpneumonectomy lung growth: mechanisms of alveolar neovascularization
M Ackermann, JP Houdek, BC Gibney, A Ysasi… - Angiogenesis, 2014 - Springer
In most rodents and some other mammals, the removal of one lung results in compensatory
growth associated with dramatic angiogenesis and complete restoration of lung capacity …
growth associated with dramatic angiogenesis and complete restoration of lung capacity …
Inhibition of Notch signaling induces extensive intussusceptive neo-angiogenesis by recruitment of mononuclear cells
I Dimova, R Hlushchuk, A Makanya, B Styp-Rekowska… - Angiogenesis, 2013 - Springer
Notch is an intercellular signaling pathway related mainly to sprouting neo-angiogenesis.
The objective of our study was to evaluate the angiogenic mechanisms involved in the …
The objective of our study was to evaluate the angiogenic mechanisms involved in the …
Bridging lung development with chronic obstructive pulmonary disease. Relevance of developmental pathways in chronic obstructive pulmonary disease …
O Boucherat, MC Morissette, S Provencher… - American journal of …, 2016 - atsjournals.org
Chronic obstructive pulmonary disease (COPD) is characterized by chronic airflow limitation.
This generic term encompasses emphysema and chronic bronchitis, two common …
This generic term encompasses emphysema and chronic bronchitis, two common …
Alveologenesis: what governs secondary septa formation
AL Rippa, EV Alpeeva, AV Vasiliev… - International Journal of …, 2021 - mdpi.com
The simplification of alveoli leads to various lung pathologies such as bronchopulmonary
dysplasia and emphysema. Deep insight into the process of emergence of the secondary …
dysplasia and emphysema. Deep insight into the process of emergence of the secondary …
Inhibiting endothelial Rhoj blocks profibrotic vascular intussusception and angiocrine factors to sustain lung regeneration
J Ma, L Zhang, X Zhang, L Zhang, H Zhang… - Science Translational …, 2024 - science.org
Lung regeneration after fibrosis requires formation of functional new vasculature, which is
essential for gas exchange and cellular cross-talk with other lung cells. It remains unknown …
essential for gas exchange and cellular cross-talk with other lung cells. It remains unknown …