Convection‐Enhanced Delivery in Malignant Gliomas: A Review of Toxicity and Efficacy

M Shi, L Sanche - Journal of oncology, 2019 - Wiley Online Library
Malignant gliomas are undifferentiated or anaplastic gliomas. They remain incurable with a
multitude of modalities, including surgery, radiation, chemotherapy, and alternating electric …

BBB-targeting, protein-based nanomedicines for drug and nucleic acid delivery to the CNS

H Peluffo, U Unzueta, ML Negro-Demontel, Z Xu… - Biotechnology …, 2015 - Elsevier
The increasing incidence of diseases affecting the central nervous system (CNS) demands
the urgent development of efficient drugs. While many of these medicines are already …

[HTML][HTML] Acoustic feedback enables safe and reliable carboplatin delivery across the blood-brain barrier with a clinical focused ultrasound system and improves …

N McDannold, Y Zhang, JG Supko, C Power, T Sun… - Theranostics, 2019 - ncbi.nlm.nih.gov
The blood-brain barrier (BBB) restricts delivery of most chemotherapy agents to brain
tumors. Here, we investigated a clinical focused ultrasound (FUS) device to disrupt the BBB …

[HTML][HTML] Convection-enhanced delivery of a virus-like nanotherapeutic agent with dual-modal imaging for besiegement and eradication of brain tumors

HH Pang, PY Chen, KC Wei, CW Huang, YL Shiue… - Theranostics, 2019 - ncbi.nlm.nih.gov
Convection-enhanced delivery (CED) is a promising technique for infusing a therapeutic
agent directly into the brain, bypassing the blood-brain barrier (BBB) with a pressure …

A novel implantable catheter system with transcutaneous port for intermittent convection-enhanced delivery of carboplatin for recurrent glioblastoma

NU Barua, K Hopkins, M Woolley, S O'Sullivan… - Drug …, 2016 - Taylor & Francis
Context: Inadequate penetration of the blood–brain barrier (BBB) by systemically
administered chemotherapies including carboplatin is implicated in their failure to improve …

Local delivery of carboplatin-loaded hydrogel and calcium carbonate enables two-stage drug release for limited-dose radiation to eliminate mouse malignant glioma

CY Hsu, J Lin, MF Wei, LH Chen, HKT Liang, FH Lin - Biomaterials, 2025 - Elsevier
Postoperative radiotherapy remains the gold standard for malignant glioma treatment.
Clinical limitations, including tumor growth between surgery and radiotherapy and the …

Convection-enhanced delivery for high-grade glioma

JH Kang, A Desjardins - Neuro-Oncology Practice, 2022 - academic.oup.com
Glioblastoma (GBM) is the most common adult primary malignant brain tumor and is
associated with a dire prognosis. Despite multi-modality therapies of surgery, radiation, and …

Evaluation of a novel sodium borocaptate-containing unnatural amino acid as a boron delivery agent for neutron capture therapy of the F98 rat glioma

G Futamura, S Kawabata, N Nonoguchi, R Hiramatsu… - Radiation …, 2017 - Springer
Background Boron neutron capture therapy (BNCT) is a unique particle radiation therapy
based on the nuclear capture reactions in boron-10. We developed a novel boron-10 …

Convection-enhanced delivery of polymeric nanoparticles encapsulating chemotherapy in canines with spontaneous supratentorial tumors

JS Young, G Bernal, SP Polster, L Nunez, GF Larsen… - World neurosurgery, 2018 - Elsevier
Background Despite aggressive multimodal treatment, survival for patients with glioblastoma
remains dismal. One obstacle to improving patient outcomes is the difficulty in delivering …

Liposomal formulations of carboplatin injected by convection-enhanced delivery increases the median survival time of F98 glioma bearing rats

M Shi, M Anantha, M Wehbe, MB Bally, D Fortin… - Journal of …, 2018 - Springer
Background Effectiveness of chemotherapy for treating glioblastoma (GBM) brain tumors is
hampered by the blood–brain barrier which limits the entry into the brain of most drugs from …