Convection‐Enhanced Delivery in Malignant Gliomas: A Review of Toxicity and Efficacy
M Shi, L Sanche - Journal of oncology, 2019 - Wiley Online Library
Malignant gliomas are undifferentiated or anaplastic gliomas. They remain incurable with a
multitude of modalities, including surgery, radiation, chemotherapy, and alternating electric …
multitude of modalities, including surgery, radiation, chemotherapy, and alternating electric …
BBB-targeting, protein-based nanomedicines for drug and nucleic acid delivery to the CNS
The increasing incidence of diseases affecting the central nervous system (CNS) demands
the urgent development of efficient drugs. While many of these medicines are already …
the urgent development of efficient drugs. While many of these medicines are already …
[HTML][HTML] Acoustic feedback enables safe and reliable carboplatin delivery across the blood-brain barrier with a clinical focused ultrasound system and improves …
N McDannold, Y Zhang, JG Supko, C Power, T Sun… - Theranostics, 2019 - ncbi.nlm.nih.gov
The blood-brain barrier (BBB) restricts delivery of most chemotherapy agents to brain
tumors. Here, we investigated a clinical focused ultrasound (FUS) device to disrupt the BBB …
tumors. Here, we investigated a clinical focused ultrasound (FUS) device to disrupt the BBB …
[HTML][HTML] Convection-enhanced delivery of a virus-like nanotherapeutic agent with dual-modal imaging for besiegement and eradication of brain tumors
Convection-enhanced delivery (CED) is a promising technique for infusing a therapeutic
agent directly into the brain, bypassing the blood-brain barrier (BBB) with a pressure …
agent directly into the brain, bypassing the blood-brain barrier (BBB) with a pressure …
A novel implantable catheter system with transcutaneous port for intermittent convection-enhanced delivery of carboplatin for recurrent glioblastoma
NU Barua, K Hopkins, M Woolley, S O'Sullivan… - Drug …, 2016 - Taylor & Francis
Context: Inadequate penetration of the blood–brain barrier (BBB) by systemically
administered chemotherapies including carboplatin is implicated in their failure to improve …
administered chemotherapies including carboplatin is implicated in their failure to improve …
Local delivery of carboplatin-loaded hydrogel and calcium carbonate enables two-stage drug release for limited-dose radiation to eliminate mouse malignant glioma
CY Hsu, J Lin, MF Wei, LH Chen, HKT Liang, FH Lin - Biomaterials, 2025 - Elsevier
Postoperative radiotherapy remains the gold standard for malignant glioma treatment.
Clinical limitations, including tumor growth between surgery and radiotherapy and the …
Clinical limitations, including tumor growth between surgery and radiotherapy and the …
Convection-enhanced delivery for high-grade glioma
JH Kang, A Desjardins - Neuro-Oncology Practice, 2022 - academic.oup.com
Glioblastoma (GBM) is the most common adult primary malignant brain tumor and is
associated with a dire prognosis. Despite multi-modality therapies of surgery, radiation, and …
associated with a dire prognosis. Despite multi-modality therapies of surgery, radiation, and …
Evaluation of a novel sodium borocaptate-containing unnatural amino acid as a boron delivery agent for neutron capture therapy of the F98 rat glioma
G Futamura, S Kawabata, N Nonoguchi, R Hiramatsu… - Radiation …, 2017 - Springer
Background Boron neutron capture therapy (BNCT) is a unique particle radiation therapy
based on the nuclear capture reactions in boron-10. We developed a novel boron-10 …
based on the nuclear capture reactions in boron-10. We developed a novel boron-10 …
Convection-enhanced delivery of polymeric nanoparticles encapsulating chemotherapy in canines with spontaneous supratentorial tumors
Background Despite aggressive multimodal treatment, survival for patients with glioblastoma
remains dismal. One obstacle to improving patient outcomes is the difficulty in delivering …
remains dismal. One obstacle to improving patient outcomes is the difficulty in delivering …
Liposomal formulations of carboplatin injected by convection-enhanced delivery increases the median survival time of F98 glioma bearing rats
Background Effectiveness of chemotherapy for treating glioblastoma (GBM) brain tumors is
hampered by the blood–brain barrier which limits the entry into the brain of most drugs from …
hampered by the blood–brain barrier which limits the entry into the brain of most drugs from …