The impact of low-protein high-carbohydrate diets on aging and lifespan
Most research on nutritional effects on aging has focussed on the impact of manipulating
single dietary factors such as total calorie intake or each of the macronutrients individually …
single dietary factors such as total calorie intake or each of the macronutrients individually …
Calorie restriction in rodents: Caveats to consider
The calorie restriction paradigm has provided one of the most widely used and most useful
tools for investigating mechanisms of aging and longevity. By far, rodent models have been …
tools for investigating mechanisms of aging and longevity. By far, rodent models have been …
Effects of sex, strain, and energy intake on hallmarks of aging in mice
Calorie restriction (CR) is the most robust non-genetic intervention to delay aging. However,
there are a number of emerging experimental variables that alter CR responses. We …
there are a number of emerging experimental variables that alter CR responses. We …
Body temperature is a more important modulator of lifespan than metabolic rate in two small mammals
Z Zhao, J Cao, C Niu, M Bao, J Xu, D Huo, S Liao… - Nature …, 2022 - nature.com
The relationships between metabolic rate, body temperature (Tb), body composition and
ageing are complex, and not fully resolved. In particular, Tb and metabolic rate often change …
ageing are complex, and not fully resolved. In particular, Tb and metabolic rate often change …
A step toward precision gerontology: Lifespan effects of calorie and protein restriction are consistent with predicted impacts on entropy generation
AS Semerciöz-Oduncuoğlu… - Proceedings of the …, 2023 - National Acad Sciences
Understanding aging is a key biological goal. Precision gerontology aims to predict how
long individuals will live under different treatment scenarios. Calorie and protein restriction …
long individuals will live under different treatment scenarios. Calorie and protein restriction …
Calories or protein? The effect of dietary restriction on lifespan in rodents is explained by calories alone
JR Speakman, SE Mitchell, M Mazidi - Experimental gerontology, 2016 - Elsevier
Almost exactly 100 years ago Osborne and colleagues demonstrated that restricting the food
intake of a small number of female rats extended their lifespan. In the 1930s experiments on …
intake of a small number of female rats extended their lifespan. In the 1930s experiments on …
Distinct and additive effects of calorie restriction and rapamycin in aging skeletal muscle
Preserving skeletal muscle function is essential to maintain life quality at high age. Calorie
restriction (CR) potently extends health and lifespan, but is largely unachievable in humans …
restriction (CR) potently extends health and lifespan, but is largely unachievable in humans …
[HTML][HTML] What is the best housing temperature to translate mouse experiments to humans?
Objectives Ambient temperature impinges on energy metabolism in a body size dependent
manner. This has implications for the housing temperature at which mice are best compared …
manner. This has implications for the housing temperature at which mice are best compared …
Molecular dynamics simulation of Doxorubicin loading with N-isopropyl acrylamide carbon nanotube in a drug delivery system
R Maleki, HH Afrouzi, M Hosseini, D Toghraie… - Computer Methods and …, 2020 - Elsevier
Abstract Background and Objective Doxorubicin is one of the common drugs used for cancer
therapy. Molecular dynamics were applied to investigate the loading of Doxorubicin with …
therapy. Molecular dynamics were applied to investigate the loading of Doxorubicin with …
Energy metabolism and ageing in the mouse: a mini-review
V Azzu, TG Valencak - Gerontology, 2017 - karger.com
The mouse has rapidly become the mammalian model organism of choice in ageing
research due to its relatively short lifespan, the proximity of its genome and physiology to …
research due to its relatively short lifespan, the proximity of its genome and physiology to …