The remarkable T cell receptor (TCR) performs essential functions in the initiation of
intracellular signals required for T cell development, repertoire selection and effector …

Thymocyte selection involves the positive and negative selection of the repertoire of T cell
receptors (TCRs) such that the organism does not suffer autoimmunity, yet has the benefit of …

Most adaptive immune responses require the activation of specific T cells through the T cell
antigen receptor (TCR)–CD3 complex. Here we show that cholesterol sulfate (CS), a …

MicroRNAs are a class of evolutionarily conserved, short non-coding RNAs that post-
transcriptionally modulate the expression of multiple target genes. They are implicated in …

The tumor microenvironment (TME) comprises a variety of immune cells, among which T
cells exert a prominent axial role in tumor development or anti-tumor responses in patients …

Thymic epithelial cells (TECs) and hematopoietic antigen presenting cells (HAPCs) in the
thymus microenvironment provide essential signals to self-reactive thymocytes that induce …

MicroRNAs have emerged as key regulators in T cell development, activation, and
differentiation, with miR-181a having a prominent function. By targeting several signaling …

Background Recent studies have revealed that multiple sclerosis (MS) lesions have distinct
microRNA (miRNA) expression profiles. miR-181 family members show altered expression …

Among T helper (Th) cell subsets differentiated from naive CD4+ T cells, IL-17-producing
Th17 cells are closely associated with the pathogenesis of autoimmune diseases, including …

Background MicroRNAs (miRNAs) have been shown to function in many different cellular
processes, including proliferation, apoptosis, differentiation and development. miR-181a …