Causes and consequences of replication stress
MK Zeman, KA Cimprich - Nature cell biology, 2014 - nature.com
Replication stress is a complex phenomenon that has serious implications for genome
stability, cell survival and human disease. Generation of aberrant replication fork structures …
stability, cell survival and human disease. Generation of aberrant replication fork structures …
SAMHD1 acts at stalled replication forks to prevent interferon induction
SAMHD1 was previously characterized as a dNTPase that protects cells from viral infections.
Mutations in SAMHD1 are implicated in cancer development and in a severe congenital …
Mutations in SAMHD1 are implicated in cancer development and in a severe congenital …
Rad51-mediated replication fork reversal is a global response to genotoxic treatments in human cells
Replication fork reversal protects forks from breakage after poisoning of Topoisomerase 1.
We here investigated fork progression and chromosomal breakage in human cells in …
We here investigated fork progression and chromosomal breakage in human cells in …
RAD52 facilitates mitotic DNA synthesis following replication stress
R Bhowmick, S Minocherhomji, ID Hickson - Molecular cell, 2016 - cell.com
Homologous recombination (HR) is necessary to counteract DNA replication stress.
Common fragile site (CFS) loci are particularly sensitive to replication stress and undergo …
Common fragile site (CFS) loci are particularly sensitive to replication stress and undergo …
ATR inhibition disrupts rewired homologous recombination and fork protection pathways in PARP inhibitor-resistant BRCA-deficient cancer cells
SA Yazinski, V Comaills, R Buisson… - Genes & …, 2017 - genesdev.cshlp.org
Poly-(ADP-ribose) polymerase (PARP) inhibitors (PARPis) selectively kill BRCA1/2-deficient
cells, but their efficacy in BRCA-deficient patients is limited by drug resistance. Here, we …
cells, but their efficacy in BRCA-deficient patients is limited by drug resistance. Here, we …
The replication checkpoint prevents two types of fork collapse without regulating replisome stability
The ATR replication checkpoint ensures that stalled forks remain stable when replisome
movement is impeded. Using an improved iPOND protocol combined with SILAC mass …
movement is impeded. Using an improved iPOND protocol combined with SILAC mass …
The Fanconi anemia pathway maintains genome stability by coordinating replication and transcription
RA Schwab, J Nieminuszczy, F Shah, J Langton… - Molecular cell, 2015 - cell.com
DNA replication stress can cause chromosomal instability and tumor progression. One key
pathway that counteracts replication stress and promotes faithful DNA replication consists of …
pathway that counteracts replication stress and promotes faithful DNA replication consists of …
ISG15 conjugation to proteins on nascent DNA mitigates DNA replication stress
CP Wardlaw, JHJ Petrini - Nature communications, 2022 - nature.com
The pathways involved in suppressing DNA replication stress and the associated DNA
damage are critical to maintaining genome integrity. The Mre11 complex is unique among …
damage are critical to maintaining genome integrity. The Mre11 complex is unique among …
ATR phosphorylates SMARCAL1 to prevent replication fork collapse
FB Couch, CE Bansbach, R Driscoll… - Genes & …, 2013 - genesdev.cshlp.org
The DNA damage response kinase ataxia telangiectasia and Rad3-related (ATR)
coordinates much of the cellular response to replication stress. The exact mechanisms by …
coordinates much of the cellular response to replication stress. The exact mechanisms by …