Spatiotemporal genomic profiling of intestinal metaplasia reveals clonal dynamics of gastric cancer progression
Intestinal metaplasia (IM) is a pre-malignant condition of the gastric mucosa associated with
increased gastric cancer (GC) risk. Analyzing 1,256 gastric samples (1,152 IMs) across 692 …
increased gastric cancer (GC) risk. Analyzing 1,256 gastric samples (1,152 IMs) across 692 …
Single-cell RNA sequencing to map tumor heterogeneity in gastric carcinogenesis paving roads to individualized therapy
J Xu, B Yu, F Wang, J Yang - Cancer Immunology, Immunotherapy, 2024 - Springer
Gastric cancer (GC) is a highly heterogeneous disease with a complex tumor
microenvironment (TME) that encompasses multiple cell types including cancer cells …
microenvironment (TME) that encompasses multiple cell types including cancer cells …
Machine learning identifies activation of RUNX/AP-1 as drivers of mesenchymal and fibrotic regulatory programs in gastric cancer
Gastric cancer (GC) is the fifth most common cancer worldwide and is a heterogeneous
disease. Among GC subtypes, the mesenchymal phenotype (Mes-like) is more invasive than …
disease. Among GC subtypes, the mesenchymal phenotype (Mes-like) is more invasive than …
Super-enhancers: Implications in gastric cancer
Y Huang, Y Huo, L Huang, L Zhang, Y Zheng… - … Research/Reviews in …, 2024 - Elsevier
Gastric cancer (GC) is the fifth most prevalent malignancy and the third leading cause of
cancer-related mortality globally. Despite intensive efforts to enhance the efficiencies of …
cancer-related mortality globally. Despite intensive efforts to enhance the efficiencies of …
Arid1a-dependent canonical BAF complex suppresses inflammatory programs to drive efficient Germinal Center B cell responses
A Abraham, D Samaniego-Castruita, I Han… - Nature …, 2024 - nature.com
Abstract The mammalian Brg1/Brm-associated factor (BAF) complexes are major regulators
of nucleosomal remodeling that are commonly mutated in several cancers, including …
of nucleosomal remodeling that are commonly mutated in several cancers, including …
Pan-cancer analysis of CDKN2A alterations identifies a subset of gastric cancer with a cold tumor immune microenvironment
C Deng, Z Li, C Xie, Q Zhang, B Hu, M Wang, J Mei… - Human Genomics, 2024 - Springer
Abstract Background Although CDKN2A alteration has been explored as a favorable factor
for tumorigenesis in pan-cancers, the association between CDKN2A point mutation (MUT) …
for tumorigenesis in pan-cancers, the association between CDKN2A point mutation (MUT) …
[HTML][HTML] The combination of exon sequencing and metabolomics to establish a molecular typing system for gastric cancer
S Yu, M Chen, X Zhu, C Chen, J Liang, H Wang, J Lu… - Heliyon, 2024 - cell.com
Background Gastric cancer (GC) is one of the most common malignant tumors in the world. It
has become increasingly difficult to meet the needs of precision therapy using the existing …
has become increasingly difficult to meet the needs of precision therapy using the existing …
Preclinical Evaluation of JAB-2485, a Potent AURKA Inhibitor with High Selectivity and Favorable Pharmacokinetic Properties
G Yang, Y Lin, X Sun, D Cheng, H Li, S Hu, M Chen… - ACS …, 2024 - ACS Publications
As a critical mitotic regulator, Aurora kinase A (AURKA) is aberrantly activated in a wide
range of cancers. Therapeutic targeting of AUKRA is a promising strategy for the treatment of …
range of cancers. Therapeutic targeting of AUKRA is a promising strategy for the treatment of …
VASN promotes the aggressive phenotype in ARID1A-deficient lung adenocarcinoma
D Wu, K Zhang, R Chen, W Ye, C Zheng, Y Zheng… - BMC cancer, 2024 - Springer
Loss of ARID1A has been reported to drive the progression of lung adenocarcinoma, yet the
underlying mechanism remains elusive. In this study, we performed secretome analysis to …
underlying mechanism remains elusive. In this study, we performed secretome analysis to …
MicroRNAs provide negative feedback and stability in gene regulatory network models of cell-state transitions
M Razavi-Mohseni, MA Beer - Frontiers in Epigenetics and …, 2024 - frontiersin.org
The development of multicellular organisms occurs through a series of cell state transitions
controlled by gene regulatory networks. Central to these networks are transcription factors …
controlled by gene regulatory networks. Central to these networks are transcription factors …