Bladder cancer is one of the most common malignancies in the world. Cisplatin is one of the
most potent and widely used anticancer drugs and has been employed in several …

Deubiquitylating enzymes (DUBs) antagonize ubiquitination by removing ubiquitin from their
substrates. The role of DUBs in controlling various physiological and pathological processes …

Ubiquitination modulates protein turnover or activity depending on the number and location
of attached ubiquitin (Ub) moieties. Proteins marked by a lysine 48 (K48)–linked …

Although certain members of the Ubiquitin-specific peptidases (USPs) have been
recognized as promising therapeutic targets for various diseases, research progress …

A substantial number of colon cancer patients do not benefit from immunotherapy using
programmed cell death 1 (PD1) antibodies. Therefore, combination therapy drugs are …

Bladder cancer is one of the common malignant urothelial tumors. Post-translational
modification (PTMs), including ubiquitination, acetylation, methylation, and phosphorylation …

Chondrosarcoma, a treatment-resistant cancer with limited therapeutic options, lacks
significant advancements in treatment methods. However, PR-619, a novel inhibitor of …

Idiopathic pulmonary fibrosis (IPF) is a chronic and lethal lung disease characterized by
progressive lung scarring. This study aims to elucidate the role of the E3 ubiquitin ligase …

High expression of ubiquitin-specific protease 10 (USP10) promote the proliferation of
hepatocellular carcinoma (HCC), thus the development of USP10 inhibitors holds promise …

Background: The inhibition of ubiquitin-specific proteases (USPs) is a novel and promising
direction in the development of molecularly targeted therapies in oncology. The aim of the …