Glycosylation is the most abundant and diverse form of post-translational modification of
proteins that is common to all eukaryotic cells. Enzymatic glycosylation of proteins involves a …

Protein posttranslational modifications (PTMs) refer to the breaking or generation of covalent
bonds on the backbones or amino acid side chains of proteins and expand the diversity of …

RTN4-binding proteins were widely studied as" NoGo" receptors, but their physiological
interactors and roles remain elusive. Similarly, BAI adhesion-GPCRs were associated with …

C-linked glycosylation is essential for the trafficking, folding and function of secretory and
transmembrane proteins involved in cellular communication processes. The tryptophan C …

Advances in nuclease-based gene-editing technologies have enabled precise, stable, and
systematic genetic engineering of glycosylation capacities in mammalian cells, opening up a …

Previous studies demonstrated importance of C-mannosylation for efficient protein secretion.
To study its impact on protein folding and stability, we analyzed both C-mannosylated and …

C-Mannosylation is a post-translational modification of proteins in the endoplasmic
reticulum. Monomeric α-mannose is attached to specific Trp residues at the first Trp in the …

Neural migration is a critical step during brain development that requires the interactions of
cell-surface guidance receptors. Cancer cells often hijack these mechanisms to disseminate …

Recombinant proteins are of paramount importance for research, industrial and medical use.
Numerous expression chassis are available for recombinant protein production, and while …

Several membrane-anchored signal mediators such as cytokines (eg TNFα) and growth
factors are proteolytically shed from the cell surface by the metalloproteinase ADAM17 …