Cellular sources of TSPO expression in healthy and diseased brain
E Nutma, K Ceyzériat, S Amor, S Tsartsalis… - European journal of …, 2021 - Springer
The 18 kDa translocator protein (TSPO) is a highly conserved protein located in the outer
mitochondrial membrane. TSPO binding, as measured with positron emission tomography …
mitochondrial membrane. TSPO binding, as measured with positron emission tomography …
Translocator protein (18 kDa)(TSPO) as a therapeutic target for neurological and psychiatric disorders
R Rupprecht, V Papadopoulos, G Rammes… - Nature reviews Drug …, 2010 - nature.com
Abstract The translocator protein (18 kDa)(TSPO) is localized primarily in the outer
mitochondrial membrane of steroid-synthesizing cells, including those in the central and …
mitochondrial membrane of steroid-synthesizing cells, including those in the central and …
VDAC, a multi-functional mitochondrial protein regulating cell life and death
V Shoshan-Barmatz, V De Pinto, M Zweckstetter… - Molecular aspects of …, 2010 - Elsevier
Research over the past decade has extended the prevailing view of the mitochondrion to
include functions well beyond the generation of cellular energy. It is now recognized that …
include functions well beyond the generation of cellular energy. It is now recognized that …
Early steps in steroidogenesis: intracellular cholesterol trafficking: thematic review series: genetics of human lipid diseases
Steroid hormones are made from cholesterol, primarily derived from lipoproteins that enter
cells via receptor-mediated endocytosis. In endo-lysosomes, cholesterol is released from …
cells via receptor-mediated endocytosis. In endo-lysosomes, cholesterol is released from …
Translocator protein (18 kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function
V Papadopoulos, M Baraldi, TR Guilarte… - Trends in …, 2006 - cell.com
The peripheral-type benzodiazepine receptor or recognition site (PBR) is a widely
distributed transmembrane protein that is located mainly in the outer mitochondrial …
distributed transmembrane protein that is located mainly in the outer mitochondrial …
Cellular cholesterol delivery, intracellular processing and utilization for biosynthesis of steroid hormones
Steroid hormones regulate diverse physiological functions such as reproduction, blood salt
balance, maintenance of secondary sexual characteristics, response to stress, neuronal …
balance, maintenance of secondary sexual characteristics, response to stress, neuronal …
Neuroinflammation and brain atrophy in former NFL players: an in vivo multimodal imaging pilot study
There are growing concerns about potential delayed, neuropsychiatric consequences (eg,
cognitive decline, mood or anxiety disorders) of sports-related traumatic brain injury (TBI) …
cognitive decline, mood or anxiety disorders) of sports-related traumatic brain injury (TBI) …
Translocator protein 18 kDa (TSPO): molecular sensor of brain injury and repair
MK Chen, TR Guilarte - Pharmacology & therapeutics, 2008 - Elsevier
For over 15 years, the peripheral benzodiazepine receptor (PBR), recently named
translocator protein 18 kDa (TSPO) has been studied as a biomarker of reactive gliosis and …
translocator protein 18 kDa (TSPO) has been studied as a biomarker of reactive gliosis and …
Cerebellum can serve as a pseudo-reference region in Alzheimer disease to detect neuroinflammation measured with PET radioligand binding to translocator protein
CH Lyoo, M Ikawa, JS Liow, SS Zoghbi… - Journal of Nuclear …, 2015 - Soc Nuclear Med
Alzheimer disease (AD) is associated with an increase in the brain of the 18-kDa
translocator protein (TSPO), which is overexpressed in activated microglia and reactive …
translocator protein (TSPO), which is overexpressed in activated microglia and reactive …
Positron emission tomography and functional characterization of a complete PBR/TSPO knockout
RB Banati, RJ Middleton, R Chan, CR Hatty… - Nature …, 2014 - nature.com
The evolutionarily conserved peripheral benzodiazepine receptor (PBR), or 18-kDa
translocator protein (TSPO), is thought to be essential for cholesterol transport and …
translocator protein (TSPO), is thought to be essential for cholesterol transport and …