Cellular sources of TSPO expression in healthy and diseased brain

E Nutma, K Ceyzériat, S Amor, S Tsartsalis… - European journal of …, 2021 - Springer
The 18 kDa translocator protein (TSPO) is a highly conserved protein located in the outer
mitochondrial membrane. TSPO binding, as measured with positron emission tomography …

Translocator protein (18 kDa)(TSPO) as a therapeutic target for neurological and psychiatric disorders

R Rupprecht, V Papadopoulos, G Rammes… - Nature reviews Drug …, 2010 - nature.com
Abstract The translocator protein (18 kDa)(TSPO) is localized primarily in the outer
mitochondrial membrane of steroid-synthesizing cells, including those in the central and …

VDAC, a multi-functional mitochondrial protein regulating cell life and death

V Shoshan-Barmatz, V De Pinto, M Zweckstetter… - Molecular aspects of …, 2010 - Elsevier
Research over the past decade has extended the prevailing view of the mitochondrion to
include functions well beyond the generation of cellular energy. It is now recognized that …

Early steps in steroidogenesis: intracellular cholesterol trafficking: thematic review series: genetics of human lipid diseases

WL Miller, HS Bose - Journal of lipid research, 2011 - ASBMB
Steroid hormones are made from cholesterol, primarily derived from lipoproteins that enter
cells via receptor-mediated endocytosis. In endo-lysosomes, cholesterol is released from …

Translocator protein (18 kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function

V Papadopoulos, M Baraldi, TR Guilarte… - Trends in …, 2006 - cell.com
The peripheral-type benzodiazepine receptor or recognition site (PBR) is a widely
distributed transmembrane protein that is located mainly in the outer mitochondrial …

Cellular cholesterol delivery, intracellular processing and utilization for biosynthesis of steroid hormones

J Hu, Z Zhang, WJ Shen, S Azhar - Nutrition & metabolism, 2010 - Springer
Steroid hormones regulate diverse physiological functions such as reproduction, blood salt
balance, maintenance of secondary sexual characteristics, response to stress, neuronal …

Neuroinflammation and brain atrophy in former NFL players: an in vivo multimodal imaging pilot study

JM Coughlin, Y Wang, CA Munro, S Ma, C Yue… - Neurobiology of …, 2015 - Elsevier
There are growing concerns about potential delayed, neuropsychiatric consequences (eg,
cognitive decline, mood or anxiety disorders) of sports-related traumatic brain injury (TBI) …

Translocator protein 18 kDa (TSPO): molecular sensor of brain injury and repair

MK Chen, TR Guilarte - Pharmacology & therapeutics, 2008 - Elsevier
For over 15 years, the peripheral benzodiazepine receptor (PBR), recently named
translocator protein 18 kDa (TSPO) has been studied as a biomarker of reactive gliosis and …

Cerebellum can serve as a pseudo-reference region in Alzheimer disease to detect neuroinflammation measured with PET radioligand binding to translocator protein

CH Lyoo, M Ikawa, JS Liow, SS Zoghbi… - Journal of Nuclear …, 2015 - Soc Nuclear Med
Alzheimer disease (AD) is associated with an increase in the brain of the 18-kDa
translocator protein (TSPO), which is overexpressed in activated microglia and reactive …

Positron emission tomography and functional characterization of a complete PBR/TSPO knockout

RB Banati, RJ Middleton, R Chan, CR Hatty… - Nature …, 2014 - nature.com
The evolutionarily conserved peripheral benzodiazepine receptor (PBR), or 18-kDa
translocator protein (TSPO), is thought to be essential for cholesterol transport and …