Natural killer cells in antitumour adoptive cell immunotherapy

TJ Laskowski, A Biederstädt, K Rezvani - Nature Reviews Cancer, 2022 - nature.com
Natural killer (NK) cells comprise a unique population of innate lymphoid cells endowed with
intrinsic abilities to identify and eliminate virally infected cells and tumour cells. Possessing …

Allogeneic natural killer cell therapy

MM Berrien-Elliott, MT Jacobs, TA Fehniger - Blood, 2023 - ashpublications.org
Interest in adoptive cell therapy for treating cancer is exploding owing to early clinical
successes of autologous chimeric antigen receptor (CAR) T lymphocyte therapy. However …

Overcoming tumor resistance mechanisms in CAR-NK cell therapy

A Valeri, A García-Ortiz, E Castellano… - Frontiers in …, 2022 - frontiersin.org
Despite the impressive results of autologous CAR-T cell therapy in refractory B
lymphoproliferative diseases, CAR-NK immunotherapy emerges as a safer, faster, and cost …

[HTML][HTML] Cytokine-induced memory-like NK cells: from the basics to clinical applications

I Terrén, A Orrantia, G Astarloa-Pando… - Frontiers in …, 2022 - frontiersin.org
Natural killer (NK) cells are lymphocytes with a key role in the defense against viral
infections and tumor cells. Although NK cells are classified as innate lymphoid cells (ILCs) …

[HTML][HTML] NK cell-based tumor immunotherapy

H Zhang, L Yang, T Wang, Z Li - Bioactive Materials, 2024 - Elsevier
Natural killer (NK) cells display a unique inherent ability to identify and eliminate virus-
infected cells and tumor cells. They are particularly powerful for elimination of hematological …

Next‐generation chimeric antigen receptors for T‐and natural killer‐cell therapies against cancer

Y Li, K Rezvani, H Rafei - Immunological Reviews, 2023 - Wiley Online Library
Adoptive cellular therapy using chimeric antigen receptor (CAR) T cells has led to a
paradigm shift in the treatment of various hematologic malignancies. However, the broad …

Chimeric antigen receptor engineered natural killer cells for cancer therapy

Y Zhang, W Zhou, J Yang, J Yang, W Wang - Experimental Hematology & …, 2023 - Springer
Natural killer (NK) cells, a unique component of the innate immune system, are inherent
killers of stressed and transformed cells. Based on their potent capacity to kill cancer cells …

Natural killer cell therapies

E Vivier, L Rebuffet, E Narni-Mancinelli, S Cornen… - Nature, 2024 - nature.com
Natural killer (NK) cells are lymphocytes of the innate immune system. A key feature of NK
cells is their ability to recognize a wide range of cells in distress, particularly tumour cells …

The application of autologous cancer immunotherapies in the age of memory-NK cells

GD Lizana-Vasquez, M Torres-Lugo, RB Dixon… - Frontiers in …, 2023 - frontiersin.org
Cellular immunotherapy has revolutionized the oncology field, yielding improved results
against hematological and solid malignancies. NK cells have become an attractive …

Microphysiological model reveals the promise of memory-like natural killer cell immunotherapy for HIV± cancer

JM Ayuso, M Farooqui, M Virumbrales-Muñoz… - nature …, 2023 - nature.com
Numerous studies are exploring the use of cell adoptive therapies to treat hematological
malignancies as well as solid tumors. However, there are numerous factors that dampen the …