During long standing hyperglycaemic state in diabetes mellitus, glucose forms covalent
adducts with the plasma proteins through a non-enzymatic process known as glycation …

The receptor for advanced glycation endproducts (RAGE) is an ubiquitous, transmembrane,
immunoglobulin-like receptor that exists in multiple isoforms and binds to a diverse range of …

Aging is the progressive accumulation of damage to an organism over time leading to
disease and death. Aging research has been very intensive in the last years aiming at …

Diabetes mellitus is a common endocrine disorder characterised by hyperglycaemia and
predisposes to chronic complications affecting the eyes, blood vessels, nerves and kidneys …

Recently, it has been proposed that the receptor for advanced glycation end-products
(RAGE) plays a crucial role in damaging cellular processes, such as neuroinflammation …

Advanced glycation end products (AGEs), S100/calgranulins, HMGB1-proteins, amyloid-β
peptides, and the family of β-sheet fibrils have been shown to contribute to a number of …

Alzheimer's disease (AD) is the most common dementing disorder of late life. Although there
might be various different triggering events in the early stages of the disease, they seem to …

The receptor for advanced glycation end products (RAGE) is a transmembrane receptor of
the immunoglobulin superfamily, capable of binding a broad repertoire of ligands. RAGE …

The endothelium is a complex organ with a multitude of properties essential for control of
vascular functions. Dysfunction of the vascular endothelium is regarded as an important …

In physiological conditions, different types of macrophages can be found within the central
nervous system (CNS), ie, microglia, meningeal macrophages, and perivascular (blood …