[HTML][HTML] Small but Highly Versatile: The Viral Accessory Protein Vpu
M Volcic, L Wiesmüller, F Kirchhoff - Annual Review of Virology, 2023 - annualreviews.org
Human and simian immunodeficiency viruses (HIVs and SIVs, respectively) encode several
small proteins (Vif, Vpr, Nef, Vpu, and Vpx) that are called accessory because they are not …
small proteins (Vif, Vpr, Nef, Vpu, and Vpx) that are called accessory because they are not …
[HTML][HTML] Key viral adaptations preceding the AIDS pandemic
D Sauter, F Kirchhoff - Cell host & microbe, 2019 - cell.com
HIV, the causative agent of AIDS, has a complex evolutionary history involving several cross-
species transmissions and recombination events as well as changes in the repertoire and …
species transmissions and recombination events as well as changes in the repertoire and …
[HTML][HTML] SARS-CoV-2 ORF3b is a potent interferon antagonist whose activity is increased by a naturally occurring elongation variant
Y Konno, I Kimura, K Uriu, M Fukushi, T Irie… - Cell reports, 2020 - cell.com
One of the features distinguishing SARS-CoV-2 from its more pathogenic counterpart SARS-
CoV is the presence of premature stop codons in its ORF3b gene. Here, we show that SARS …
CoV is the presence of premature stop codons in its ORF3b gene. Here, we show that SARS …
[HTML][HTML] Sarbecovirus ORF6 proteins hamper induction of interferon signaling
I Kimura, Y Konno, K Uriu, K Hopfensperger, D Sauter… - Cell reports, 2021 - cell.com
The presence of an ORF6 gene distinguishes sarbecoviruses such as severe acute
respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2 from other …
respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2 from other …
[HTML][HTML] A CRISPR-Cas Cure for HIV/AIDS
M Hussein, MA Molina, B Berkhout… - International journal of …, 2023 - mdpi.com
Human immunodeficiency virus (HIV) infections and HIV-induced acquired
immunodeficiency syndrome (AIDS) continue to represent a global health burden. There is …
immunodeficiency syndrome (AIDS) continue to represent a global health burden. There is …
[HTML][HTML] HIV-1 Vpu is a potent transcriptional suppressor of NF-κB-elicited antiviral immune responses
Many viral pathogens target innate sensing cascades and/or cellular transcription factors to
suppress antiviral immune responses. Here, we show that the accessory viral protein U …
suppress antiviral immune responses. Here, we show that the accessory viral protein U …
CpG Frequency in the 5′ Third of the env Gene Determines Sensitivity of Primary HIV-1 Strains to the Zinc-Finger Antiviral Protein
CpG dinucleotide suppression has been reported to allow HIV-1 to evade inhibition by the
zinc-finger antiviral protein (ZAP). Here, we show that primate lentiviruses display marked …
zinc-finger antiviral protein (ZAP). Here, we show that primate lentiviruses display marked …
Antiviral factors and their counteraction by HIV-1: Many uncovered and more to be discovered
D Kmiec, F Kirchhoff - Journal of Molecular Cell Biology, 2024 - academic.oup.com
Extensive studies on HIV-1 have led to the discovery of a variety of structurally and
functionally diverse innate defense factors that target various steps of the retroviral …
functionally diverse innate defense factors that target various steps of the retroviral …
Vpu modulates DNA repair to suppress innate sensing and hyper-integration of HIV-1
M Volcic, KMJ Sparrer, L Koepke, D Hotter… - Nature …, 2020 - nature.com
To avoid innate sensing and immune control, human immunodeficiency virus type 1 (HIV-1)
has to prevent the accumulation of viral complementary DNA species. Here, we show that …
has to prevent the accumulation of viral complementary DNA species. Here, we show that …
[HTML][HTML] HIV-1 Vpu restricts Fc-mediated effector functions in vivo
Non-neutralizing antibodies (nnAbs) can eliminate HIV-1-infected cells via antibody-
dependent cellular cytotoxicity (ADCC) and were identified as a correlate of protection in the …
dependent cellular cytotoxicity (ADCC) and were identified as a correlate of protection in the …