Sirtuins are NAD+-dependent histone deacetylases regulating important metabolic
pathways in prokaryotes and eukaryotes and are involved in many biological processes …

Sirtuins are NAD+ dependent histone deacetylases (HDAC) that play a pivotal role in
neuroprotection and cellular senescence. SIRT1-7 are different homologs from sirtuins. They …

Here we report the development of a proteolysis targeting chimera (PROTAC) based on the
combination of the unique features of the sirtuin rearranging ligands (SirReals) as highly …

Abstract Sirtuin (Yeast Silent Information RegulatorsⅡ, Sir2) was first discovered in the
1970s. Because of its function by removing acetylated groups from histones in the presence …

Currently, the development of anticancer drug resistance is significantly restricted the clinical
efficacy of the most commonly prescribed anticancer drug. Malignant disease is widely …

Sirtuins are NAD+‐dependent protein deacylases that cleave off acetyl, as well as other acyl
groups, from the ε‐amino group of lysines in histones and other substrate proteins. Seven …

Dysregulation of both tubulin deacetylases sirtuin 2 (Sirt2) and the histone deacetylase 6
(HDAC6) has been associated with the pathogenesis of cancer and neurodegeneration …

Abstract A series of 1, 3, 4-thiadiazole-5, 6-diphenyl-triazine hybrids 7a-l have been
designed, synthesized and investigated for the α-glucosidase inhibitory activities. All the …

Herin we report the design, synthesis, full characterization and biological investigation of
new 15-LOX/COX dual inhibitors based on 1, 3-thiazolidin-4-one (15-lipoxygenase …

Abstract Sirtuins (SIRT1–7) are distinct histone deacetylases (HDACs) whose activity is
determined by cellular metabolic status andnicotinamide adenine dinucleotide (NAD+) …