Specialized subpopulations of CD4+ T cells survey major histocompatibility complex class II–
peptide complexes to control phagosomal infections, help B cells, regulate tissue …

Autoimmune hepatitis (AIH) is a T-cell mediated, inflammatory liver disease affecting all
ages and characterized by female preponderance, elevated serum transaminase and …

Metabolic activity is intimately linked to T cell fate and function. Using high-resolution mass
spectrometry, we generated dynamic metabolome and proteome profiles of human primary …

Narcolepsy is a chronic sleep disorder caused by the loss of neurons that produce
hypocretin. The close association with HLA-DQB1* 06: 02, evidence for immune …

In 1986, Mosmann and Coffman identified 2 functionally distinct subsets of activated CD4 T
cells, Th1 and Th2 cells, being key in distinct T cell mediated responses. Over the past three …

Abstract IL-17-producing CD4+ T helper cells (TH17) have been extensively investigated in
mouse models of autoimmunity. However, the requirements for differentiation and the …

Human beings are exposed to a variety of different pathogens, which induce tailored
immune responses and consequently generate highly diverse populations of pathogen …

Background Parkinson's disease (PD) affects an estimated 7 to 10 million people worldwide,
and only symptomatic treatments are presently available to relieve the consequences of …

CD4+ T helper (Th) cells play a central role in the adaptive immune response by providing
help to B cells and cytotoxic T cells and by releasing different types of cytokines in tissues to …

The possibility of HIV-1 eradication has been limited by the existence of latently infected
cellular reservoirs. Studies to examine control of HIV latency and potential reactivation have …