Cu (I)-catalyzed azide–alkyne cycloaddition (CuAAC) is a modular and bio-orthogonal
approach that is being adopted for the efficient synthesis of organic and bioorganic …

The covalent immobilisation of enzymes generally involves the use of highly reactive
crosslinkers, such as glutaraldehyde, to couple enzyme molecules to each other or to …

The surging development of bioorthogonal chemistry has profoundly transformed chemical
biology over the last two decades. Involving chemical partners that specifically react together …

Click chemistry has been proven to be very useful in drug delivery. Due to the availability of
a large number of click reactions with a various characteristics, selection of appropriate …

Click chemistry is a set of easy, atom-economical reactions that are often utilized to combine
two desired chemical entities. Click chemistry accelerates lead identification and …

The ability to site-specifically modify proteins at multiple sites in vivo will enable the study of
protein function in its native environment with unprecedented levels of detail. Here, we …

Over the past decade, several different metal‐free bioorthogonal reactions have been
developed to enable simultaneous double‐click labeling with minimal‐to‐no competing …

Two pyrene-tetrazole conjugates were synthesized as photoreactive chromophores that
allow for the first time the combination of metabolic labelling of DNA in cells and subsequent …

Targeted radionuclide therapy (TRNT) is an ever-expanding field of nuclear medicine that
provides a personalised approach to cancer treatment while limiting toxicity to normal …

In the quest to scrutinize and modify biological systems, the global research community has
continued to explore bio-orthogonal click reactions, a set of reactions exclusively targeting …