Mechanism of ferroptosis and its role in type 2 diabetes mellitus

W Sha, F Hu, Y Xi, Y Chu, S Bu - Journal of diabetes research, 2021 - Wiley Online Library
Ferroptosis is a novel form of nonapoptotic regulated cell death (RCD). It features iron‐
dependent lipid peroxide accumulation accompanied by inadequate redox enzymes …

Programmed cell-death by ferroptosis: antioxidants as mitigators

N Kajarabille, GO Latunde-Dada - International journal of molecular …, 2019 - mdpi.com
Iron, the fourth most abundant element in the Earth's crust, is vital in living organisms
because of its diverse ligand-binding and electron-transfer properties. This ability of iron in …

Quercetin alleviates ferroptosis of pancreatic β cells in type 2 diabetes

D Li, C Jiang, G Mei, Y Zhao, L Chen, J Liu, Y Tang… - Nutrients, 2020 - mdpi.com
(1) Background: Pancreatic iron deposition has been found in the progression of type 2
diabetes (T2DM); however, whether ferroptosis contributes to the dysfunction of pancreatic β …

Ferroptosis as a mechanism of neurodegeneration in Alzheimer's disease

M Jakaria, AA Belaidi, AI Bush… - Journal of …, 2021 - Wiley Online Library
Alzheimer's disease (AD) is the most prevalent form of dementia, with complex
pathophysiology that is not fully understood. While β‐amyloid plaque and neurofibrillary …

Green tea derivative (−)-epigallocatechin-3-gallate (EGCG) confers protection against ionizing radiation-induced intestinal epithelial cell death both in vitro and in vivo

LW Xie, S Cai, TS Zhao, M Li, Y Tian - Free Radical Biology and Medicine, 2020 - Elsevier
Radiation-induced intestinal injury (RIII) occurs during instances of intentional or accidental
radiation exposure. However, there are few effective treatments available for the prevention …

[HTML][HTML] Epigallocatechin-3-gallate pretreatment alleviates doxorubicin-induced ferroptosis and cardiotoxicity by upregulating AMPKα2 and activating adaptive …

H He, L Wang, Y Qiao, B Yang, D Yin, M He - Redox Biology, 2021 - Elsevier
Reports indicate that the mechanism of doxorubicin (Dox)-induced cardiotoxicity is very
complex, involving multiple regulatory cell death forms. Furthermore, the clinical intervention …

[HTML][HTML] EF24 induces ferroptosis in osteosarcoma cells through HMOX1

H Lin, X Chen, C Zhang, T Yang, Z Deng… - Biomedicine & …, 2021 - Elsevier
Purpose EF24, a synthetic analogue of curcumin, was developed as an anti-tumor
compound to induce apoptosis, inhibit proliferation and metastasis in various cancers …

Cellular senescence and regulated cell death of tubular epithelial cells in diabetic kidney disease

S Shen, C Ji, K Wei - Frontiers in Endocrinology, 2022 - frontiersin.org
Cellular senescence is frequently evident at etiologic sites of chronic diseases and involves
essentially irreversible arrest of cell proliferation, increased protein production, resistance to …

Zooming in and out of ferroptosis in human disease

X Wang, Y Zhou, J Min, F Wang - Frontiers of Medicine, 2023 - Springer
Ferroptosis is defined as an iron-dependent regulated form of cell death driven by lipid
peroxidation. In the past decade, it has been implicated in the pathogenesis of various …

Ferroptosis in rheumatoid arthritis: a potential therapeutic strategy

T Zhao, Q Yang, Y Xi, Z Xie, J Shen, Z Li, Z Li… - Frontiers in …, 2022 - frontiersin.org
Ferroptosis is one of the newly discovered forms of cell-regulated death characterized by
iron-dependent lipid peroxidation. Extensive research has focused on the roles of ferroptosis …