[HTML][HTML] The cellular and molecular basis for planarian regeneration
PW Reddien - Cell, 2018 - cell.com
Regeneration is one of the great mysteries of biology. Planarians are flatworms capable of
dramatic feats of regeneration, which have been studied for over 2 centuries. Recent …
dramatic feats of regeneration, which have been studied for over 2 centuries. Recent …
Model systems for regeneration: planarians
M Ivankovic, R Haneckova, A Thommen… - …, 2019 - journals.biologists.com
Planarians are a group of flatworms. Some planarian species have remarkable regenerative
abilities, which involve abundant pluripotent adult stem cells. This makes these worms a …
abilities, which involve abundant pluripotent adult stem cells. This makes these worms a …
Cell type atlas and lineage tree of a whole complex animal by single-cell transcriptomics
INTRODUCTION Understanding the differentiation of stem cells into the vast amount of cell
types that form the human body is a central problem of basic and medical science. The …
types that form the human body is a central problem of basic and medical science. The …
Cell type transcriptome atlas for the planarian Schmidtea mediterranea
CT Fincher, O Wurtzel, T de Hoog, KM Kravarik… - Science, 2018 - science.org
INTRODUCTION The complete sequence of animal genomes has had a transformative
impact on biological research. Whereas the genome sequence of an organism contains the …
impact on biological research. Whereas the genome sequence of an organism contains the …
Identification of rare, transient post-mitotic cell states that are induced by injury and required for whole-body regeneration in Schmidtea mediterranea
BW Benham-Pyle, CE Brewster, AM Kent… - Nature cell …, 2021 - nature.com
Regeneration requires the coordination of stem cells, their progeny and distant differentiated
tissues. Here, we present a comprehensive atlas of whole-body regeneration in Schmidtea …
tissues. Here, we present a comprehensive atlas of whole-body regeneration in Schmidtea …
[HTML][HTML] Planarian stem cells specify fate yet retain potency during the cell cycle
Planarian whole-body regeneration is enabled by stem cells called neoblasts. At least some
neoblasts are individually pluripotent. Neoblasts are also heterogeneous, with …
neoblasts are individually pluripotent. Neoblasts are also heterogeneous, with …
[HTML][HTML] Fate specification is spatially intermingled across planarian stem cells
C Park, KE Owusu-Boaitey, GM Valdes… - Nature …, 2023 - nature.com
Regeneration requires mechanisms for producing a wide array of cell types. Neoblasts are
stem cells in the planarian Schmidtea mediterranea that undergo fate specification to …
stem cells in the planarian Schmidtea mediterranea that undergo fate specification to …
Chromatin analysis of adult pluripotent stem cells reveals a unique stemness maintenance strategy
A Poulet, AJ Kratkiewicz, D Li, JC van Wolfswinkel - Science Advances, 2023 - science.org
Many highly regenerative organisms maintain adult pluripotent stem cells throughout their
life, but how the long-term maintenance of pluripotency is accomplished is unclear. To …
life, but how the long-term maintenance of pluripotency is accomplished is unclear. To …
[HTML][HTML] ACME dissociation: a versatile cell fixation-dissociation method for single-cell transcriptomics
H García-Castro, NJ Kenny, M Iglesias… - Genome biology, 2021 - Springer
Single-cell sequencing technologies are revolutionizing biology, but they are limited by the
need to dissociate live samples. Here, we present ACME (ACetic-MEthanol), a dissociation …
need to dissociate live samples. Here, we present ACME (ACetic-MEthanol), a dissociation …
[HTML][HTML] Muscle functions as a connective tissue and source of extracellular matrix in planarians
LE Cote, E Simental, PW Reddien - Nature communications, 2019 - nature.com
Regeneration and tissue turnover require new cell production and positional information.
Planarians are flatworms capable of regenerating all body parts using a population of stem …
Planarians are flatworms capable of regenerating all body parts using a population of stem …