Regeneration is one of the great mysteries of biology. Planarians are flatworms capable of
dramatic feats of regeneration, which have been studied for over 2 centuries. Recent …

Planarians are a group of flatworms. Some planarian species have remarkable regenerative
abilities, which involve abundant pluripotent adult stem cells. This makes these worms a …

INTRODUCTION Understanding the differentiation of stem cells into the vast amount of cell
types that form the human body is a central problem of basic and medical science. The …

INTRODUCTION The complete sequence of animal genomes has had a transformative
impact on biological research. Whereas the genome sequence of an organism contains the …

Regeneration requires the coordination of stem cells, their progeny and distant differentiated
tissues. Here, we present a comprehensive atlas of whole-body regeneration in Schmidtea …

Planarian whole-body regeneration is enabled by stem cells called neoblasts. At least some
neoblasts are individually pluripotent. Neoblasts are also heterogeneous, with …

Regeneration requires mechanisms for producing a wide array of cell types. Neoblasts are
stem cells in the planarian Schmidtea mediterranea that undergo fate specification to …

Many highly regenerative organisms maintain adult pluripotent stem cells throughout their
life, but how the long-term maintenance of pluripotency is accomplished is unclear. To …

Single-cell sequencing technologies are revolutionizing biology, but they are limited by the
need to dissociate live samples. Here, we present ACME (ACetic-MEthanol), a dissociation …

Regeneration and tissue turnover require new cell production and positional information.
Planarians are flatworms capable of regenerating all body parts using a population of stem …