Macrophages represent heterogeneous cell population with important roles in defence
mechanisms and in homoeostasis. Tissue macrophages from diverse anatomical locations …

Macrophages have protective roles in immunity to pathogens, tissue development,
homeostasis and repair following damage. Maladaptive immunity and inflammation provoke …

Chronic hepatitis B is caused by prolonged infection with the hepatitis B virus (HBV), which
can substantially increase the risk of developing liver disease. Despite the development of …

Liver allograft rejection remains a significant cause of morbidity and graft failure in liver
transplant recipients. Rejection is caused by the recognition of non-self donor alloantigens …

Inducing graft acceptance without chronic immunosuppression remains an elusive goal in
organ transplantation. Using an experimental transplantation mouse model, we demonstrate …

Burn is an under-appreciated trauma that is associated with unacceptably high morbidity
and mortality. Although the survival rate after devastating burn injuries has continued to …

Tumor-associated myeloid cells maintain immunosuppressive microenvironments within
tumors. Identification of myeloid-specific receptors to modulate tumor-associated …

IgG antibodies are secreted from B cells and bind to a variety of pathogens to control
infections as well as contribute to inflammatory diseases. Many of the functions of IgGs are …

Pathogen recognition by C-type lectin receptors (CLRs) expressed by dendritic cells is
important not only for antigen presentation, but also for the induction of appropriate adaptive …

A bottleneck for immunotherapy of cancer is the immunosuppressive microenvironment in
which the tumor cells proliferate. Cancers harness the immune regulatory mechanism that …