This review focuses on the multiple and reciprocal relationships that exist between oxidative
stress, hyperglycemia and diabetes and related metabolic disorders. Human metabolism …

Mammalian target of rapamycin (mTOR) is a serine/threonine kinase that gets inputs from
the amino acids, nutrients, growth factor, and environmental cues to regulate varieties of …

Transcription factors (TFs) are key regulators of intrinsic cellular processes, such as
differentiation and development, and of the cellular response to external perturbation …

The gut-microbe-derived metabolite trimethylamine N-oxide (TMAO) is increased by insulin
resistance and associated with several sequelae of metabolic syndrome in humans …

Sunitinib resistance is a major challenge for advanced renal cell carcinoma (RCC).
Understanding the underlying mechanisms and developing effective strategies against …

Many transcription factors play a key role in cellular differentiation and the delineation of cell
phenotype. Transcription factors are regulated by phosphorylation, ubiquitination …

The regulation of oxidative stress is an important factor in both tumour development and
responses to anticancer therapies. Many signalling pathways that are linked to …

Transcription factors of the forkhead box, class O (FoxO) family are important regulators of
the cellular stress response and promote the cellular antioxidant defense. On one hand …

Thirty years ago, a novel axis of the renin-angiotensin system (RAS) was unveiled by the
discovery of angiotensin-(1− 7)[ANG-(1− 7)] generation in vivo. Later, angiotensin …

Ageing is affected by both genetic and non-genetic factors. Here, we review the chromatin-
based epigenetic changes that occur during ageing, the role of chromatin modifiers in …