One of the first biological machineries to be created seems to have been the ribosome.
Since then, organisms have dedicated great efforts to optimize this apparatus. The …

Ribosomes are highly conserved ribonucleoprotein nanomachines that translate information
in the genome to create the proteome in all cells. In yeast these complex particles contain …

Availability of key nutrients, such as sugars, amino acids, and nitrogen compounds, dictates
the developmental programs and the growth rates of yeast cells. A number of overlapping …

We define the activity and mechanisms of action of a small molecule lead compound for
cancer targeting. We show that the compound, BMH-21, has wide and potent …

Accurate DNA replication and DNA repair are crucial for the maintenance of genome
stability, and it is generally accepted that failure of these processes is a major source of DNA …

Ribosomes provide the basis for protein production and this drives cell growth. Recent
studies, both in yeast and in higher eukaryotes, are beginning to reveal new mechanisms …

Transcription of ribosomal RNA by RNA polymerase (Pol) I initiates ribosome biogenesis
and regulates eukaryotic cell growth. The crystal structure of Pol I from the yeast …

Abstract RNA Polymerase (Pol) I produces ribosomal (r) RNA, an essential component of the
cellular protein synthetic machinery that drives cell growth, underlying many fundamental …

Chromatin endogenous cleavage (ChEC) uses fusion of a protein of interest to micrococcal
nuclease (MNase) to target calcium-dependent cleavage to specific genomic loci in vivo …

Mapping open chromatin regions has emerged as a widely used tool for identifying active
regulatory elements in eukaryotes. However, existing approaches, limited by reliance on …