Mathematical analysis of HIV-1 dynamics in vivo

AS Perelson, PW Nelson - SIAM review, 1999 - SIAM
Mathematical models have proven valuable in understanding the dynamics of HIV-1
infection in vivo. By comparing these models to data obtained from patients undergoing …

Dynamics of HIV infection of CD4+ T cells

AS Perelson, DE Kirschner, R De Boer - Mathematical biosciences, 1993 - Elsevier
We examine a model for the interaction of HIV with CD4+ T cells that considers four
populations: uninfected T cells, latently infected T cells, actively infected T cells, and free …

Virus dynamics: a global analysis

HL Smith, P De Leenheer - SIAM Journal on Applied Mathematics, 2003 - SIAM
Exploiting the fact that standard models of within-host viral infections of target cell
populations by HIV, developed by Perelson and Nelson [SIAM Rev., 41 (1999), pp. 3--44] …

Modeling plasma virus concentration during primary HIV infection

MA Stafford, L Corey, Y Cao, ES Daar, DD Ho… - Journal of theoretical …, 2000 - Elsevier
During primary HIV infection the viral load in plasma increases, reaches a peak, and then
declines. Phillips has suggested that the decline is due to a limitation in the number of cells …

Modeling antiretroviral drug responses for HIV-1 infected patients using differential equation models

Y Xiao, H Miao, S Tang, H Wu - Advanced drug delivery reviews, 2013 - Elsevier
We review mathematical modeling and related statistical issues of HIV dynamics primarily in
response to antiretroviral drug therapy in this article. We start from a basic model of virus …

Statistical methods for HIV dynamic studies in AIDS clinical trials

H Wu - Statistical methods in medical research, 2005 - journals.sagepub.com
Studies of HIV dynamics in AIDS research are very important for understanding
pathogenesis of HIV infection and for assessing the potency of antiviral therapies. Since the …

Modeling the interaction of the immune system with HIV

AS Perelson - Mathematical and statistical approaches to AIDS …, 1989 - Springer
The interactions between the human immune system and HIV are potentially complex. In this
paper I review some of these interactions and sketch the beginnings of a general model that …

Stochastic theory of early viral infection: continuous versus burst production of virions

JE Pearson, P Krapivsky… - PLoS computational …, 2011 - journals.plos.org
Viral production from infected cells can occur continuously or in a burst that generally kills
the cell. For HIV infection, both modes of production have been suggested. Standard viral …

Modeling HIV dynamics and antiviral response with consideration of time-varying drug exposures, adherence and phenotypic sensitivity

Y Huang, SL Rosenkranz, H Wu - Mathematical biosciences, 2003 - Elsevier
Highly active antiretroviral therapies consisting of reverse transcriptase inhibitor drugs and
protease inhibitor drugs, which can rapidly suppress HIV below the limit of detection, are …

A stochastic model of latently infected cell reactivation and viral blip generation in treated HIV patients

JM Conway, D Coombs - PLoS computational biology, 2011 - journals.plos.org
Motivated by viral persistence in HIV+ patients on long-term anti-retroviral treatment (ART),
we present a stochastic model of HIV viral dynamics in the blood stream. We consider the …