Alcohol dehydrogenases (ADHs) are most known for their roles in oxidation and elimination
of ethanol. Although less known, ADHs also play a critical role in the metabolism of a …

Mainly known for its more famous parent compound, ethanol, acetaldehyde was first studied
in the 1940s, but then research interest in this compound waned. However, in the last two …

Chronic alcohol intake leads to neuroinflammation and cell injury, proposed to result in
alterations that perpetuate alcohol intake and cued relapse. Studies show that brain …

Alcohol consumption dates back to the Neolithic period, and alcohol dependence
contributes substantially to the current global burden of disease. Despite this, optimal …

Ethanol consumption has effects on the central nervous system (CNS), manifesting as motor
incoordination, sleep induction (hypnosis), anxiety, amnesia, and the reinforcement or …

Background Incentives to promote drinking (“happy hour”) can encourage faster rates of
alcohol consumption, especially in women. Sex differences in drinking dynamics may …

Chronic ethanol consumption leads to brain oxidative stress and neuroinflammation,
conditions known to potentiate and perpetuate each other. Several studies have shown that …

The putative contribution of brain acetaldehyde (AcH) to ethanol (EtOH) tolerance and
dependence (addiction) is reviewed. Although the role of AcH in EtOH addiction has been …

The goal of the present studies was to determine long-lasting effects of adolescent
intermittent ethanol (AIE), a rodent model of binge patterns of ethanol consumption, on (i) …

Ethanol-induced behavioral sensitization (EBS) was first described in 1980, approximately
10 years after the phenomenon was described for psychostimulants. Ethanol acts on γ …