Recent data have suggested a key role for tumor necrosis factor (TNF)-α in the insulin
resistance of obesity and non-insulin-dependent diabetes mellitus (NIDDM). TNF-α …

In mammals, insulin is the principal hormone controlling blood glucose and acts by
stimulating glucose influx and metabolism in muscle and adipocytes and inhibiting …

Obesity is frequently associated with insulin resistance and abnormal glucose homeostasis.
Recent studies in animal models have indicated that TNF-alpha plays an important role in …

Insulin resistance is a common problem associated with infections and cancer and, most
importantly, is the central component of non-insulin-dependent diabetes mellitus. We have …

Hepatic steatosis is present in insulin-resistant obese rodents and is concomitant with active
lipogenesis. Hepatic lipogenesis depends on the insulin-induced activation of the …

In animal studies, increased amounts of triglyceride associated with skeletal muscle (mTG)
correlate with reduced skeletal muscle and whole body insulin action. The aim of this study …

Both insulin resistance (type II diabetes) and β-amyloid (Aβ) oligomers are implicated in
Alzheimer's disease (AD). Here, we investigate the role of Aβ oligomer-induced c-Jun N …

THE principal substrate for the insulin and insulin-like growth factor-1 (IGF-1) receptors is the
cytoplasmic protein insulin-receptor substrate-1 (IRS-l/pplSS) 1–7. After tyrosine …

Insulin resistance is an important metabolic abnormality often associated with infections,
cancer, obesity, and especially non-insulin-dependent diabetes mellitus (NIDDM). We have …

Hotamisligil GS (Harvard University, Boston, Massachusetts, USA). The role of TNFα and
TNF receptors in obesity and insulin resistance.(Minisymposium: Genes & Obesity). J Intern …