Gut microbiota has implications in Central Nervous System (CNS) disorders. Our study
systematically identified preclinical studies aimed to investigate the possible gut microbiota …

Neuropathic pain (NPP) is a common syndrome associated with most forms of cancer, which
poses a serious threat to human health. NPP may persist even after the nociceptive …

Central post-stroke pain (CPSP) and associated depression remain poorly understood and
pharmacological treatments are unsatisfactory. Recently, microglia activation was suggested …

Chronic sampling of tonic serotonin (5-hydroxytryptamine, 5-HT) concentrations in the brain
is critical for tracking neurological disease development and the time course of …

Aims Epidemiological studies in patients with neuropathic pain have demonstrated a strong
association between neuropathic pain and psychiatric conditions such as anxiety …

The amygdala plays a critical role in the emotional-affective component of pain and pain
modulation. The central nucleus of amygdala (CeA) serves major output functions and has …

Neuropathic pain is generally defined as a non-physiological pain experience caused by
damage to the nervous system. It can occur spontaneously, as a reaction to a given stimulus …

Clinically, neuropathic pain treatment remains a challenging issue because the major
therapy, centred around pharmacological intervention, is not satisfactory enough to patient …

Dopamine (DA) plays a central role in the modulation of various physiological brain
functions, including learning, motivation, reward, and movement control. The DA dynamic …

Neuropathic pain has long-term consequences in affective and cognitive disturbances,
suggesting the involvement of supraspinal mechanisms. In this study, we used the spared …