TRAP1 is a component of a pro-survival mitochondrial pathway up-regulated in tumor cells.
The evaluation of TRAP1 expression in 26 human colorectal carcinomas showed up …

TRAP1 is a mitochondrial antiapoptotic protein up-regulated in several human
malignancies. However, recent evidences suggest that TRAP1 is also localized in the …

Chemoresistance is a leading cause of morbidity and mortality in patients with pancreatic
cancer and remains an obstacle to successful treatment. The antioxidant transcription factor …

The Ca2+-binding protein sorcin regulates intracellular calcium homeostasis and plays a
role in the induction of drug resistance in human cancers. Recently, an 18 kDa mitochondrial …

Background: LncRNA is an important regulatory factor in the human genome. We aim to
explore the roles of LncFALEC and miR-20a-5p/SHOC2 axis on the proliferation, migration …

Thyroid carcinomas (TCs) bearing BRAF mutations represent approximately 26–53% of
human thyroid malignancies and, differently from melanomas, are poorly sensitive to BRAF …

Purpose To investigate the use of liposomal irinotecan (Irinophore C™) plus or minus 5-
fluorouracil (5-FU) for the treatment of colorectal cancer. Experimental Design The effect of …

Adaptation to endoplasmic reticulum (ER) stress through the upregulation of the ER
chaperone BiP/Grp78 favors resistance of cancer cells to anthracyclins. We recently …

Application of anthracyclines and Vinca alkaloids on the same day represents a hallmark of
polychemotherapy protocols for hematopoietic malignancies. Here we show, for the first …

Background and Purpose In polychemotherapy protocols, that is for treatment of
neuroblastoma and E wing sarcoma, Vinca alkaloids and cell cycle‐arresting drugs are …