Avian MHC evolution in the era of genomics: phase 1.0

EA O'Connor, H Westerdahl, R Burri, SV Edwards - Cells, 2019 - mdpi.com
Birds are a wonderfully diverse and accessible clade with an exceptional range of ecologies
and behaviors, making the study of the avian major histocompatibility complex (MHC) of …

Evolution of copy number at the MHC varies across the avian tree of life

P Minias, E Pikus, LA Whittingham… - Genome Biology and …, 2019 - academic.oup.com
The evolution of the major histocompatibility complex (MHC) is shaped by frequent gene
duplications and deletions, which generate extensive variation in the number of loci (gene …

A review of suggested mechanisms of MHC odor signaling

M Milinski - Biology, 2022 - mdpi.com
Simple Summary Immune genes of the vertebrate MHC vary among individuals. Each
individual collection is optimally diverse to provide resistance against some infectious …

The genomic architecture of the passerine MHC region: High repeat content and contrasting evolutionary histories of single copy and tandemly duplicated MHC genes

H Westerdahl, S Mellinger, H Sigeman… - Molecular Ecology …, 2022 - Wiley Online Library
The major histocompatibility complex (MHC) is of central importance to the immune system,
and an optimal MHC diversity is believed to maximize pathogen elimination. Birds show …

A global analysis of selection at the avian MHC

P Minias, E Pikus, LA Whittingham, PO Dunn - Evolution, 2018 - academic.oup.com
Recent advancements in sequencing technology have resulted in rapid progress in the
study of the major histocompatibility complex (MHC) in non-model avian species. Here, we …

Evolution of major histocompatibility complex gene copy number

P Bentkowski, J Radwan - PLOS Computational Biology, 2019 - journals.plos.org
MHC genes, which code for proteins responsible for presenting pathogen-derived antigens
to the host immune system, show remarkable copy-number variation both between and …

Ecology can inform genetics: Disassortative mating contributes to MHC polymorphism in Leach's storm‐petrels (Oceanodroma leucorhoa)

B Hoover, M Alcaide, S Jennings, SYW Sin… - Molecular …, 2018 - Wiley Online Library
Studies of MHC‐based mate choice in wild populations often test hypotheses on species
exhibiting female choice and male–male competition, which reflects the general prevalence …

Extensive MHC class IIβ diversity across multiple loci in the small-spotted catshark (Scyliorhinus canicula)

A Gaigher, A Rota, F Neves, A Muñoz-Mérida… - Scientific Reports, 2023 - nature.com
The major histocompatibility complex (MHC) is a multigene family responsible for pathogen
detection, and initiation of adaptive immune responses. Duplication, natural selection …

Whole‐genome sequencing and genome regions of special interest: Lessons from major histocompatibility complex, sex determination, and plant self‐incompatibility

X Vekemans, V Castric, H Hipperson… - Molecular …, 2021 - Wiley Online Library
Whole‐genome sequencing of non‐model organisms is now widely accessible and has
allowed a range of questions in the field of molecular ecology to be investigated with greater …

Blood parasites shape extreme major histocompatibility complex diversity in a migratory passerine

A Biedrzycka, W Bielański, A Ćmiel, W Solarz… - Molecular …, 2018 - Wiley Online Library
Pathogens are one of the main forces driving the evolution and maintenance of the highly
polymorphic genes of the vertebrate major histocompatibility complex (MHC). Although MHC …