Increased risky choice during forced abstinence from fentanyl on the cued rat gambling task

KM Hrelja, C Kawkab, DK Avramidis, S Ramaiah… - …, 2024 - Springer
Rationale The use of illicit opioids has arguably never been more risky; street drug potency
can be dangerously high, is often unknown to the consumer, and results in multiple daily …

Propensity for risky choices despite lower cue reactivity in adolescent rats

S Zeng, EFB McLaughlin, A Ramesh… - Frontiers in Behavioral …, 2023 - frontiersin.org
Adolescence is a time of heightened risk-taking across species. Salient audiovisual cues
associated with rewards are a common feature of gambling environments and have been …

Dissociable roles of the mPFC-to-VTA Pathway in the control of Impulsive Action and Risk-Related Decision-Making in Roman High-And Low-Avoidance Rats

G Urueña-Méndez, C Arrondeau… - International Journal …, 2024 - academic.oup.com
Background Impulsive action and risk-related decision-making (RDM) are associated with
various psychiatric disorders including drug abuse. Both behavioral traits have also been …

Dopamine activity in the nigrostriatal pathway alters cue‐induced risky choice patterns in female rats

BA Hathaway, A Li, HG Brodie… - European Journal of …, 2024 - Wiley Online Library
Deficits in cost/benefit decision making is a critical risk factor for gambling disorder. Reward‐
paired cues may play an important role, as these stimuli can enhance risk preference in rats …

Towards a better understanding of the bidirectional relationship between decision-making and addiction vulnerability

KM Hrelja - 2024 - open.library.ubc.ca
Impaired decision-making is recognized as a diagnostic criterion for many different
psychiatric disorders including gambling disorder and substance use disorders. Habit …