The dual role of HLA-C in tolerance and immunity at the maternal-fetal interface
H Papúchová, TB Meissner, Q Li… - Frontiers in …, 2019 - frontiersin.org
To establish a healthy pregnancy, maternal immune cells must tolerate fetal allo-antigens
and remain competent to respond to infections both systemically and in placental tissues …
and remain competent to respond to infections both systemically and in placental tissues …
Generalists and specialists: a new view of how MHC class I molecules fight infectious pathogens
J Kaufman - Trends in Immunology, 2018 - cell.com
In comparison with the major histocompatibility complexes (MHCs) of typical mammals, the
chicken MHC is simple and compact with a single dominantly expressed class I molecule …
chicken MHC is simple and compact with a single dominantly expressed class I molecule …
Elevated HLA-A expression impairs HIV control through inhibition of NKG2A-expressing cells
The highly polymorphic human leukocyte antigen (HLA) locus encodes cell surface proteins
that are critical for immunity. HLA-A expression levels vary in an allele-dependent manner …
that are critical for immunity. HLA-A expression levels vary in an allele-dependent manner …
Comparison between qPCR and RNA-seq reveals challenges of quantifying HLA expression
Human leukocyte antigen (HLA) class I and II loci are essential elements of innate and
acquired immunity. Their functions include antigen presentation to T cells leading to cellular …
acquired immunity. Their functions include antigen presentation to T cells leading to cellular …
Expression estimation and eQTL mapping for HLA genes with a personalized pipeline
The HLA (Human Leukocyte Antigens) genes are well-documented targets of balancing
selection, and variation at these loci is associated with many disease phenotypes. Variation …
selection, and variation at these loci is associated with many disease phenotypes. Variation …
Approaching genetics through the MHC lens: tools and methods for HLA research
V Douillard, EC Castelli, SJ Mack, JA Hollenbach… - Frontiers in …, 2021 - frontiersin.org
The current SARS-CoV-2 pandemic era launched an immediate and broad response of the
research community with studies both about the virus and host genetics. Research in …
research community with studies both about the virus and host genetics. Research in …
Host genetic variation and HIV disease: from mapping to mechanism
V Naranbhai, M Carrington - Immunogenetics, 2017 - Springer
This review aims to provide a summary of current knowledge of host genetic effects on
human immunodeficiency virus (HIV) disease. Mapping of simple single nucleotide …
human immunodeficiency virus (HIV) disease. Mapping of simple single nucleotide …
The MHC in the era of next-generation sequencing: Implications for bridging structure with function
EW Petersdorf, C O'hUigin - Human immunology, 2019 - Elsevier
The MHC continues to have the most disease-associations compared to other regions of the
human genome, even in the genome-wide association study (GWAS) and single nucleotide …
human genome, even in the genome-wide association study (GWAS) and single nucleotide …
Identification of novel genetic risk factors for focal segmental glomerulosclerosis in children: results from the Chronic Kidney Disease in Children (CKiD) Cohort
A Durand, CA Winkler, N Vince, V Douillard… - American Journal of …, 2023 - Elsevier
Rationale & Objective Focal segmental glomerulosclerosis (FSGS) is a major cause of
pediatric nephrotic syndrome, and African Americans exhibit an increased risk for …
pediatric nephrotic syndrome, and African Americans exhibit an increased risk for …
[HTML][HTML] Variants at HLA-A, HLA-C, and HLA-DQB1 confer risk of psoriasis vulgaris in Japanese
Psoriasis vulgaris (PsV) is an autoimmune disease of skin and joints with heterogeneity in
epidemiologic and genetic landscapes of global populations. We conducted an initial …
epidemiologic and genetic landscapes of global populations. We conducted an initial …