Neurological disorders such as Alzheimer's disease, stroke, and brain cancers are difficult to
treat with current drugs as their delivery efficacy to the brain is severely hampered by the …

The blood–brain barrier (BBB) is a barrier that separates the blood from the brain tissue and
possesses unique characteristics that make the delivery of drugs to the brain a great …

The specific diagnosis and treatment of gliomas is a primary challenge in clinic due to their
high invasiveness and blood-brain barrier (BBB) obstruction. It is highly desirable to find a …

This review focuses on the smart chemistry that has been utilized in developing polymer-
based drug delivery systems over the past 10 years. We provide a comprehensive overview …

Incorporating labile bonds inside polymer backbone and side chains yields interesting
polymer materials that are responsive to change of environmental stimuli. Drugs can be …

Periodontitis is a chronic inflammatory disease initiated by pathogenic biofilms and host
immunity that damages tooth-supporting tissues, including the gingiva, periodontal ligament …

Gliomas are the most common tumor of the central nervous system. However, the presence
of the brain barrier blocks the effective delivery of drugs and leads to the treatment failure of …

Hydrogels based on chitosan/hyaluronic acid/β-sodium glycerophosphate demonstrate
injectability, body temperature sensitivity, pH sensitive drug release and adhesion to cancer …

High-grade glioma is one of the most aggressive types of cancer with a low survival rate
ranging from 12 to 15 months after the first diagnosis. Though being the most common …

Functionalized drug delivery systems against malignant lung metastasis of breast cancer
have been extensively studied, while metastasis remains a challenging issue. We propose a …