The general secretory (Sec) pathway comprises an essential, ubiquitous and universal
export machinery for most proteins that integrate into, or translocate through, the plasma …

The signal recognition particle (SRP) and its receptor compose a universally conserved and
essential cellular machinery that couples the synthesis of nascent proteins to their proper …

Existing high-throughput methods to identify RNA-binding proteins (RBPs) are based on
capture of polyadenylated RNAs and cannot recover proteins that interact with …

As nascent polypeptides exit ribosomes, they are engaged by a series of processing,
targeting, and folding factors. Here, we present a selective ribosome profiling strategy that …

The timely production of functional proteins is of critical importance for the biological activity
of cells. To reach the functional state, newly synthesized polypeptides have to become …

The Sec61 or SecY channel, a universally conserved protein-conducting channel,
translocates proteins across and integrates proteins into the eukaryotic endoplasmic …

Each peptide bond of a protein is generated at the peptidyl transferase center (PTC) of the
ribosome and then moves through the exit tunnel, which accommodates ever-changing …

Protein transport via the Sec translocon represents an evolutionary conserved mechanism
for delivering cytosolically-synthesized proteins to extra-cytosolic compartments. The Sec …

Maintaining a functional proteome under different environmental conditions is challenging
for every organism, in particular for unicellular organisms, such as bacteria. In order to cope …

Gram negative bacteria possess a large variety of protein transport systems, by which
proteins that are synthesised in the cytosol are exported to destinations in the cell envelope …