The cohesin complex, encoded by SMC3, SMC1A, RAD21, and STAG2, is a critical
regulator of DNA-looping and gene expression. Over a decade has passed since recurrent …

Alternative splicing (AS) functions as a crucial program in transcriptional modulation, leading
to proteomic diversity and functional alterations of proteins. These splicing actions induce …

Cohesin shapes the chromatin architecture, including enhancer-promoter interactions. Its
components, especially STAG2, but not its paralog STAG1, are frequently mutated in …

Cohesin, a crucial regulator of genome organisation, plays a fundamental role in
maintaining chromatin architecture as well as gene expression. Among its subunits, STAG2 …

Hypomethylating agents (HMAs) are the standard of care for patients with higher-risk
myelodysplastic neoplasms (HR-MDS) and, in combination with venetoclax, for patients with …

The treatment of acute myeloid leukemia (AML) with adverse genetics remains
unsatisfactory, with very low response rates to standard chemotherapy and shorter durations …

Simple Summary Therapeutic advances in acute myeloid leukemia (AML) are dependent on
identifying and targeting the molecular aberrations that drive disease. The European …

Mutations in the cohesin complex components (STAG2, RAD21, SMC1A, SMC3, and
PDS5B) are recurrent genetic drivers in myelodysplastic neoplasm (MDS) and acute …

Although advancements in genomic and epigenetic research have deepened our
understanding of acute myeloid leukemia (AML), only one-third of patients can achieve …

Recurrent somatic mutations in the genes encoding the chromatin-regulatory cohesin
complex and its modulators occur in a wide range of human malignancies including a high …