All living organisms depend on primary and secondary membrane transport for the supply of
external nutrients and removal or sequestration of unwanted (toxic) compounds. Due to the …

SUMMARY ATP-binding cassette (ABC) systems are universally distributed among living
organisms and function in many different aspects of bacterial physiology. ABC transporters …

ABC transporters mediate active translocation of a diverse range of molecules across all cell
membranes. They comprise two nucleotide-binding domains (NBDs) and two …

Membrane proteins responsible for the active efflux of structurally and functionally unrelated
drugs were first characterized in higher eukaryotes. To date, a vast number of transporters …

Multidrug ABC transporters such as the human multidrug resistance P-glycoprotein (ABCB1)
play an important role in the extrusion of drugs from the cell and their overexpression can be …

The ATP-binding cassette (ABC) transporter associated with antigen processing (TAP)
participates in immune surveillance by moving proteasomal products into the endoplasmic …

Abstract ATP-Binding Cassette (ABC) transporters are a broad family of biological machines,
found in most prokaryotic and eukaryotic cells, performing the crucial import or export of …

Polarized transport of the plant hormone auxin influences multiple growth processes in
plants and is regulated by plasma-membrane-localized efflux and uptake carriers. The PGP …

Sav1866 is an ATP-binding cassette (ABC) protein from the pathogen Staphylococcus
aureus and is a homologue of bacterial and human multidrug ABC transporters. Recently …

ATP-binding cassette transporters mediate the transbilayer movement of a vast number of
substrates in or out of cells in organisms ranging from bacteria to humans. Current …