Natural killer (NK) cells, a subgroup of innate lymphoid cells, act as the first line of defense
against cancer. Although some evidence shows that NK cells can develop in secondary …

Oncolytic viruses (OVs) provide novel and promising therapeutic options for patients with
cancers resistant to traditional therapies. Natural or genetically modified OVs are …

Oncolytic viruses (OV) selectively replicate and kill cancer cells and spread within the tumor,
while not harming normal tissue. In addition to this direct oncolytic activity, OVs are also very …

Why do we grow up to look, act, and feel as we do? Through most of the twentieth century,
scientists and laypeople answered this question by referring to two factors alone: our …

Oncolytic viruses (OVs) are tumor-selective, multi-mechanistic antitumor agents. They kill
infected cancer and associated endothelial cells via direct oncolysis, and uninfected cells …

Breast cancer brain metastases (BCBMs) are common in patients with metastatic breast
cancer and indicate a poor prognosis. These tumors are especially resistant to currently …

Persistent latent reservoir of replication-competent proviruses in memory CD4 T cells is a
major obstacle to curing HIV infection. Pharmacological activation of HIV expression in …

Many cancers possess the ability to suppress the immune response to malignant cells, thus
facilitating tumour growth and invasion, and this has fuelled research to reverse these …

Oncolytic viruses (OVs) target and destroy cancer cells while sparing their normal
counterparts. These viruses have been evaluated in numerous studies at both pre-clinical …

Herpes simplex virus (HSV) can be genetically altered to acquire oncolytic properties so that
oncolytic HSV (oHSV) preferentially replicates in and kills cancer cells, while sparing normal …