Mitochondria-derived peptides in aging and healthspan
The mechanisms that explain mitochondrial dysfunction in aging and healthspan continue to
be studied, but one element has been unexplored: microproteins. Small open reading …
be studied, but one element has been unexplored: microproteins. Small open reading …
Mitochondrial-derived peptides in energy metabolism
TL Merry, A Chan, JST Woodhead… - American Journal …, 2020 - journals.physiology.org
Mitochondrial-derived peptides (MDPs) are small bioactive peptides encoded by short open-
reading frames (sORF) in mitochondrial DNA that do not necessarily have traditional …
reading frames (sORF) in mitochondrial DNA that do not necessarily have traditional …
Mitochondrial DNA variation in Alzheimer's disease reveals a unique microprotein called SHMOOSE
Mitochondrial DNA variants have previously associated with disease, but the underlying
mechanisms have been largely elusive. Here, we report that mitochondrial SNP rs2853499 …
mechanisms have been largely elusive. Here, we report that mitochondrial SNP rs2853499 …
Peptides derived from small mitochondrial open reading frames: Genomic, biological, and therapeutic implications
Mitochondrial-derived peptides (MDPs) are a novel class of bioactive microproteins that
modify cell metabolism. The the eight MDPs that been characterized (eg, humanin, MOTS-c …
modify cell metabolism. The the eight MDPs that been characterized (eg, humanin, MOTS-c …
Extending human healthspan and longevity: a symposium report
LM DeVito, N Barzilai, AM Cuervo… - Annals of the New …, 2022 - Wiley Online Library
For many years, it was believed that the aging process was inevitable and that age‐related
diseases could not be prevented or reversed. The geroscience hypothesis, however, posits …
diseases could not be prevented or reversed. The geroscience hypothesis, however, posits …
Novel insights into mitochondrial DNA: mitochondrial microproteins and mtDNA variants modulate athletic performance and age-related diseases
Sports genetics research began in the late 1990s and over 200 variants have been reported
as athletic performance-and sports injuries-related genetic polymorphisms. Genetic …
as athletic performance-and sports injuries-related genetic polymorphisms. Genetic …
Spatial distribution and source identification of potentially toxic elements in Yellow River Delta soils, China: An interpretable machine-learning approach
M Zhou, Y Li - Science of The Total Environment, 2024 - Elsevier
Identifying the driving factors and quantifying the sources of potentially toxic elements
(PTEs) are essential for protecting the ecological environment of the Yellow River Delta. In …
(PTEs) are essential for protecting the ecological environment of the Yellow River Delta. In …
[HTML][HTML] A pro-diabetogenic mtDNA polymorphism in the mitochondrial-derived peptide, MOTS-c
Abstract Type 2 Diabetes (T2D) is an emerging public health problem in Asia. Although
ethnic specific mtDNA polymorphisms have been shown to contribute to T2D risk, the …
ethnic specific mtDNA polymorphisms have been shown to contribute to T2D risk, the …
Mitochondria in Mycobacterium Infection: From the Immune System to Mitochondrial Haplogroups
FG Souza, GC Cavalcante - International Journal of Molecular Sciences, 2022 - mdpi.com
In humans, mitochondria play key roles in the regulation of cellular functions, such as the
regulation of the innate immune response and are targets of several pathogenic viruses and …
regulation of the innate immune response and are targets of several pathogenic viruses and …
[HTML][HTML] Mitochondrial-derived microproteins: from discovery to function
Given the uniqueness of the mitochondria, and the fact that they have their own genome,
mitochondrial-derived microproteins (MDPs) are similar to, but different from, nuclear …
mitochondrial-derived microproteins (MDPs) are similar to, but different from, nuclear …