Advances in genomics have deepened our understanding of the biology of acute
lymphoblastic leukemia (ALL), defined novel molecular leukemia subtypes, discovered new …

Philadelphia Chromosome–Like Acute Lymphoblastic Leukemia: Progress in a New Cancer
Subtype Page 1 554 Clinical Advances in Hematology & Oncology Volume 15, Issue 7 July 2017 …

Objectives: Cytokine receptor–like factor 2 (CRLF2) rearrangement is found in
approximately 50% of pediatric Ph-like B-cell acute lymphoblastic leukemia (B-ALL), and …

Overexpression of cytokine receptor-like factor 2 (CRLF2) resulting from its genomic
rearrangement is the most frequent genetic alteration found in Philadelphia chromosome …

This study aimed to investigate the combined impact of IKZF1 deletions/high expression of
CRLF2 on the prognosis of pediatric B-cell precursor acute lymphoblastic leukemia (BCP …

Background The prognostic significance of cytokine receptor-like factor 2 (CRLF2)
overexpression in pediatric B-cell precursor (BCP) acute lymphoblastic leukemia (ALL) is …

Although pediatric-like treatment regimen has remarkably improved the survival rates of
adults with acute lymphoblastic leukemia (ALL), the outcome of some adult patients is still …

The IKAROS family zinc finger 1 (IKZF1) gene is frequently altered in adults with B cell acute
lymphoblastic leukemia (ALL). Although many studies have indicated that IKZF1 alterations …

The multiplex ligation-dependent probe amplification (MLPA) method was used to detect the
copy number alterations (CNAs) of IKAROS family zinc finger 1 (IKZF1), paired box 5 …

Background IKZF1 deletions are associated with adverse outcomes in B-cell acute
lymphoblastic leukemia (B-ALL). We assessed the prevalence and clinical impact of …