Tyrosinase is a multi-copper enzyme which is widely distributed in different organisms and
plays an important role in the melanogenesis and enzymatic browning. Therefore, its …

Tyrosinase is a copper-containing metalloenzyme that is responsible for the rate-limiting
catalytic step in the melanin biosynthesis and enzymatic browning. As a promising target …

Tyrosinase is a copper-containing oxidation enzyme, which is responsible for the production
of melanin. This enzyme is widely distributed in microorganisms, animals and plants, and …

The search of new antioxidants, as drugs candidates, is an active field of medicinal
chemistry. The synthesis of compounds with antioxidant potential has increased in recent …

A series of gallic acid-benzylidenehydrazine hybrids were synthesized and evaluated for
their tyrosinase inhibitory activity. Thereinto, compounds 5d and 5f potently inhibited …

Hybrid drugs featuring two or more potentially bioactive pharmacophores have been
recognized as advanced and superior chemical entities to simultaneously modulate multiple …

Tyrosinase is involved in the synthesis of neuromelanin in the substantia nigra, which is
closely correlated with the pathogenesis of Parkinson's disease. Herein, we identified …

In the present work, a small library of novel pyrazolinyl-acyl thiourea (5a–j) was designed
and synthesized through a multistep sequence and the synthesized compounds were …

Considering highly valuable biological and pharmaceutical properties of coumarins, the
synthesis of these heterocycles has been considered for many organic and pharmaceutical …

Cancer represents the main cause of morbidity and mortality worldwide, constituting a
serious health problem. In this context, melanoma represents the most aggressive and fatal …