Emerging data suggest that SSeCKS/Gravin/AKAP12 (“AKAP12”), originally identified as an
autoantigen in cases of myasthenia gravis, controls multiple biological processes through its …

Cancer development is a multifactorial process resulting from the aberrant activation of
multiple signaling pathways. It has become increasingly clear that the coordination of the …

Background Statistical analysis of DNA microarray data provides a valuable diagnostic tool
for the investigation of genetic components of diseases. To take advantage of the multitude …

Background The human cell cycle transcription factor FOXM1 is known to play a key role in
regulating timely mitotic progression and accurate chromosomal segregation during cell …

The primary or acquired resistance to anti-VEGF inhibitors remains a common problem in
cancer treatment. Therefore, identifying potential biomarkers enables a better understanding …

A-kinase anchor protein 12 (AKAP12) also known as Gravin and SSeCKS, is a novel potent
scaffold protein for many key signaling factors, such as protein kinase C (PKC), PKA, cyclins …

The development of cancer is a complex process that requires the participation of many
factors, including mutations in genes, regulation of signaling pathways, disruption of …

Summary Purpose:: Colorectal cancer (CRC) is a common and potentially lethal disease. A
number of genetic aberrations is known to take place in colorectal carcinogenesis, which …

Background: AKAP12 inhibits oncogenic proliferation, invasion, chemotaxis and
neovascularization. Bcl-2 and p53 are two important apoptotic markers that play roles in …

Our previous study reported that retinoic acid induced 16 (RAI16) could enhance
tumorigenesis in hepatocellular carcinoma (HCC). However, the cellular functions of RAI16 …