TGFβ signalling has key roles in cancer progression: most carcinoma cells have inactivated
their epithelial antiproliferative response and benefit from increased TGFβ expression and …

Transforming growth factor-β (TGFβ) isoforms are upregulated and activated in myocardial
diseases and have an important role in cardiac repair and remodelling, regulating the …

The liver is the largest solid organ in the body, yet it remains incompletely characterized.
Here we present a spatial proteogenomic atlas of the healthy and obese human and murine …

Transforming growth factor-β (TGF-β) represents an evolutionarily conserved family of
secreted polypeptide factors that regulate many aspects of physiological embryogenesis …

Transforming growth factor-βs (TGF-βs) and bone morphometric proteins (BMPs) belong to
the TGF-β superfamily and perform essential functions during osteoblast and chondrocyte …

Transforming growth factor β (TGF-β) family members signal via heterotetrameric complexes
of type I and type II dual specificity kinase receptors. The activation and stability of the …

Inhibitory Smads (I-Smads) have conserved carboxy-terminal MH2 domains but highly
divergent amino-terminal regions when compared with receptor-regulated Smads (R …

Bone morphogenetic proteins (BMPs), originally identified as osteoinductive components in
extracts derived from bone, are now known to play important roles in a wide array of …

Atherosclerosis is an inflammatory disease resulting in the hardening and thickening of the
wall of arteries and the formation of plaques, which comprise immune cells, mesenchymal …

Abstract γδT cells have been reported to exert immunosuppressive functions in multiple
solid malignant diseases, but their immunosuppressive functional subpopulation in breast …