Research and practice in critical care medicine have long been defined by syndromes,
which, despite being clinically recognizable entities, are, in fact, loose amalgams of …

Sepsis is defined as a life-threatening organ dysfunction caused by a dysregulated host
response to an infection. This recently implemented definition does not capture the …

Sepsis arises from diverse and incompletely understood dysregulated host response
processes following infection that leads to life-threatening organ dysfunction. Here we …

Heterogeneity in sepsis and acute respiratory distress syndrome (ARDS) is increasingly
being recognized as one of the principal barriers to finding efficacious targeted therapies …

Background In sepsis and acute respiratory distress syndrome (ARDS), heterogeneity has
contributed to difficulty identifying effective pharmacotherapies. In ARDS, two molecular …

Over the last years, there have been advances in the use of data-driven techniques to
improve the definition, early recognition, subtypes characterisation, prognostication and …

Sepsis has been identified by the World Health Organization (WHO) as a global health
priority. There has been a tremendous effort to decipher underlying mechanisms …

Sepsis is a heterogeneous disease state that is both common and consequential in critically
ill patients. Unfortunately, the heterogeneity of sepsis at the individual patient level has …

Purpose Using latent class analysis (LCA), we have consistently identified two distinct
subphenotypes in four randomized controlled trial cohorts of ARDS. One subphenotype has …

Despite progress in the supportive care available for critically ill patients, few advances have
been made in the search for effective disease-modifying therapeutic options. The fact that …