Tauopathies: new perspectives and challenges
Y Zhang, KM Wu, L Yang, Q Dong, JT Yu - Molecular neurodegeneration, 2022 - Springer
Background Tauopathies are a class of neurodegenerative disorders characterized by
neuronal and/or glial tau-positive inclusions. Main body Clinically, tauopathies can present …
neuronal and/or glial tau-positive inclusions. Main body Clinically, tauopathies can present …
RNA modifications and RNA metabolism in neurological disease pathogenesis
B Chatterjee, CKJ Shen, P Majumder - International journal of molecular …, 2021 - mdpi.com
The intrinsic cellular heterogeneity and molecular complexity of the mammalian nervous
system relies substantially on the dynamic nature and spatiotemporal patterning of gene …
system relies substantially on the dynamic nature and spatiotemporal patterning of gene …
Neurons and glial cells acquire a senescent signature after repeated mild traumatic brain injury in a sex-dependent manner
N Schwab, D Taskina, E Leung, BT Innes… - Frontiers in …, 2022 - frontiersin.org
Mild traumatic brain injury (mTBI) is an important public health issue, as it can lead to long-
term neurological symptoms and risk of neurodegenerative disease. The pathophysiological …
term neurological symptoms and risk of neurodegenerative disease. The pathophysiological …
Mass spectrometry–based proteomics analysis of human substantia nigra from Parkinson's disease patients identifies multiple pathways potentially involved in the …
Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder
characterized by the loss of dopaminergic neurons in the substantia nigra (SN) of the brain …
characterized by the loss of dopaminergic neurons in the substantia nigra (SN) of the brain …
Genome organization around nuclear speckles drives mRNA splicing efficiency
The nucleus is highly organized, such that factors involved in the transcription and
processing of distinct classes of RNA are confined within specific nuclear bodies,. One …
processing of distinct classes of RNA are confined within specific nuclear bodies,. One …
Tip60's novel RNA-binding function modulates alternative splicing of pre-mRNA targets implicated in Alzheimer's disease
A Bhatnagar, K Krick, BC Karisetty… - Journal of …, 2023 - Soc Neuroscience
The severity of Alzheimer9s disease (AD) progression involves a complex interplay of
genetics, age, and environmental factors orchestrated by histone acetyltransferase (HAT) …
genetics, age, and environmental factors orchestrated by histone acetyltransferase (HAT) …
Sleep and memory: The impact of sleep deprivation on transcription, translational control, and protein synthesis in the brain
LC Lyons, Y Vanrobaeys, T Abel - Journal of neurochemistry, 2023 - Wiley Online Library
In countries around the world, sleep deprivation represents a widespread problem affecting
school‐age children, teenagers, and adults. Acute sleep deprivation and more chronic sleep …
school‐age children, teenagers, and adults. Acute sleep deprivation and more chronic sleep …
Comprehensive analysis of alternative splicing across multiple transcriptomic cohorts reveals prognostic signatures in prostate cancer
Background Alternative splicing (AS) plays a crucial role in transcriptomic diversity and is a
hallmark of cancer that profoundly influences the development and progression of prostate …
hallmark of cancer that profoundly influences the development and progression of prostate …
Splice-modulating antisense oligonucleotides as therapeutics for inherited metabolic diseases
Abstract The last decade (2013–2023) has seen unprecedented successes in the clinical
translation of therapeutic antisense oligonucleotides (ASOs). Eight such molecules have …
translation of therapeutic antisense oligonucleotides (ASOs). Eight such molecules have …
Oligonucleotide correction of an intronic TIMMDC1 variant in cells of patients with severe neurodegenerative disorder
R Kumar, MA Corbett, NJC Smith, DH Hock… - NPJ Genomic …, 2022 - nature.com
TIMMDC1 encodes the T ranslocase of I nner M itochondrial M embrane D omain-C
ontaining protein 1 (TIMMDC1) subunit of complex I of the electron transport chain …
ontaining protein 1 (TIMMDC1) subunit of complex I of the electron transport chain …