Recent advancements in the development of anti-tuberculosis drugs
S Chetty, M Ramesh, A Singh-Pillay… - Bioorganic & medicinal …, 2017 - Elsevier
Modern chemotherapy has significantly improved patient outcomes against drug-sensitive
tuberculosis. However, the rapid emergence of drug-resistant tuberculosis, together with the …
tuberculosis. However, the rapid emergence of drug-resistant tuberculosis, together with the …
Aminoacyl-tRNA synthetases in the bacterial world
R Giegé, M Springer - EcoSal Plus, 2016 - Am Soc Microbiol
Aminoacyl-tRNA synthetases (aaRSs) are modular enzymes globally conserved in the three
kingdoms of life. All catalyze the same two-step reaction, ie, the attachment of a …
kingdoms of life. All catalyze the same two-step reaction, ie, the attachment of a …
Discovery of a potent benzoxaborole-based anti-pneumococcal agent targeting leucyl-tRNA synthetase
Streptococcus pneumoniae causes bacterial pneumonia with high mortality and morbidity.
The emergency of multidrug-resistant bacteria threatens the treatment of the disease. Leucyl …
The emergency of multidrug-resistant bacteria threatens the treatment of the disease. Leucyl …
The isolated carboxy‐terminal domain of human mitochondrial leucyl‐tRNA synthetase rescues the pathological phenotype of mitochondrial tRNA mutations in human …
E Perli, C Giordano, A Pisano, A Montanari… - EMBO molecular …, 2014 - embopress.org
Mitochondrial (mt) diseases are multisystem disorders due to mutations in nuclear or mtDNA
genes. Among the latter, more than 50% are located in transfer RNA (tRNA) genes and are …
genes. Among the latter, more than 50% are located in transfer RNA (tRNA) genes and are …
Insights into the Effects of Ligand Binding on Leucyl-tRNA Synthetase Inhibitors for Tuberculosis: In Silico Analysis and Isothermal Titration Calorimetry Validation
Incidences of drug-resistant tuberculosis have become common and are rising at an
alarming rate. Aminoacyl t-RNA synthetase has been validated as a newer target against …
alarming rate. Aminoacyl t-RNA synthetase has been validated as a newer target against …
Acetylation of lysine ϵ-amino groups regulates aminoacyl-tRNA synthetase activity in Escherichia coli
Previous proteomic analyses have shown that aminoacyl-tRNA synthetases in many
organisms can be modified by acetylation of Lys. In this present study, leucyl-tRNA …
organisms can be modified by acetylation of Lys. In this present study, leucyl-tRNA …
Coexistence of bacterial leucyl-tRNA synthetases with archaeal tRNA binding domains that distinguish tRNALeu in the archaeal mode
Leucyl-tRNA (transfer RNA) synthetase (LeuRS) is a multi-domain enzyme, which is divided
into bacterial and archaeal/eukaryotic types. In general, one specific LeuRS, the domains of …
into bacterial and archaeal/eukaryotic types. In general, one specific LeuRS, the domains of …
A bridge between the aminoacylation and editing domains of leucyl-tRNA synthetase is crucial for its synthetic activity
Leucyl-tRNA synthetases (LeuRSs) catalyze the linkage of leucine with tRNALeu. LeuRS
contains a catalysis domain (aminoacylation) and a CP1 domain (editing). CP1 is inserted …
contains a catalysis domain (aminoacylation) and a CP1 domain (editing). CP1 is inserted …
Identification of lethal mutations in yeast threonyl-tRNA synthetase revealing critical residues in its human homolog
Aminoacyl-tRNA synthetases (aaRSs) are a group of ancient enzymes catalyzing
aminoacylation and editing reactions for protein biosynthesis. Increasing evidence suggests …
aminoacylation and editing reactions for protein biosynthesis. Increasing evidence suggests …
Clinical feature and molecular diagnostic analysis of the first non-caucasian child with infantile liver failure syndrome type 1
WX Lin, QQ Zheng, L Guo, Y Cheng… - … Dang dai er ke za zhi …, 2017 - europepmc.org
婴儿肝衰竭综合征 1 型 (ILFS1) 是一种由胞质亮氨酰-tRNA 合成酶基因 (LARS)
突变所导致的常染色体隐性遗传病. 本研究报道首例非白人 ILFS1 患者的临床特点和分子诊断 …
突变所导致的常染色体隐性遗传病. 本研究报道首例非白人 ILFS1 患者的临床特点和分子诊断 …